3TDJ

Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM-97 at 1.95 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GLU A 401

Chain	Residue
A	TYR61
A	HOH279
A	HOH292
A	HOH318
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	GLY141
A	SER142
A	THR143
A	GLU193

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 265

Chain	Residue
A	ALA63
A	SER140
A	LYS144
A	ARG148
A	HOH333
A	HOH374
A	HOH425

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 266

Chain	Residue
A	ARG163

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 267

Chain	Residue
A	ALA153

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 268

Chain	Residue
A	LYS240
A	GLN244
A	GOL269
A	HOH447
B	LYS151
B	HOH513

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 269

Chain	Residue
A	LYS240
A	GLU243
A	GOL268
A	HOH404
A	HOH447
B	ARG149

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 270

Chain	Residue
A	ARG148
A	TRP159
A	ARG163

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 271

Chain	Residue
A	ASP248
A	HOH392
B	ASN214
B	ASP216
B	SER217

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 272

Chain	Residue
A	MET19
A	HIS23
A	ARG31
A	HOH360
A	HOH504
B	LYS183

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 273

Chain	Residue
A	LYS116
A	LYS117
A	THR119

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 274

Chain	Residue
A	LYS50
A	TYR51

---

site_id	BC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 3TJ B 400

Chain	Residue
A	LYS104
A	PRO105
A	PHE106
A	MET107
A	SER108
A	SER242
B	ILE92
B	PRO105
B	MET107
B	SER108
B	SER217
B	LYS218
B	GLY219
B	3TJ265

---

site_id	BC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 3TJ B 265

Chain	Residue
A	ILE92
A	PRO105
A	SER108
A	SER217
A	LYS218
A	GLY219
A	HOH428
B	LYS104
B	PRO105
B	PHE106
B	MET107
B	SER108
B	SER242
B	3TJ400

---

site_id	BC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU B 399

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	LEU138
B	GLY141
B	SER142
B	THR143
B	GLU193
B	HOH277
B	HOH281
B	HOH319

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 266

Chain	Residue
B	SER140
B	LYS144
B	ARG148
B	HOH315
B	HOH356
B	HOH438

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 267

Chain	Residue
B	ARG148
B	TRP159
B	ARG163
B	HOH540

---

site_id	BC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL B 268

Chain	Residue
B	GLY62
B	ALA63
B	TRP71
B	THR93
B	ARG96
B	GLU145
B	HOH315
B	HOH426
B	HOH439

---

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B 269

Chain	Residue
B	SER108
B	SER194
B	GLU198
B	ASN214
B	HOH361
B	HOH410

---

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 270

Chain	Residue
A	LYS258
B	HIS23
B	ARG31
B	HOH341

---

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 271

Chain	Residue
B	GLU27
B	GLY28
B	ARG31
B	LYS52
B	HOH371

---

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B 272

Chain	Residue
B	LYS116
B	LYS185
B	HOH374

---

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 273

Chain	Residue
B	LYS4
B	THR5
B	HOH465

---

site_id	CC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 274

Chain	Residue
B	LYS82
B	LYS116

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---