Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GLU A 401 |
| Chain | Residue |
| A | TYR61 |
| A | HOH279 |
| A | HOH292 |
| A | HOH318 |
| A | PRO89 |
| A | LEU90 |
| A | THR91 |
| A | ARG96 |
| A | GLY141 |
| A | SER142 |
| A | THR143 |
| A | GLU193 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 265 |
| Chain | Residue |
| A | ALA63 |
| A | SER140 |
| A | LYS144 |
| A | ARG148 |
| A | HOH333 |
| A | HOH374 |
| A | HOH425 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 266 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 267 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 268 |
| Chain | Residue |
| A | LYS240 |
| A | GLN244 |
| A | GOL269 |
| A | HOH447 |
| B | LYS151 |
| B | HOH513 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 269 |
| Chain | Residue |
| A | LYS240 |
| A | GLU243 |
| A | GOL268 |
| A | HOH404 |
| A | HOH447 |
| B | ARG149 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 270 |
| Chain | Residue |
| A | ARG148 |
| A | TRP159 |
| A | ARG163 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 271 |
| Chain | Residue |
| A | ASP248 |
| A | HOH392 |
| B | ASN214 |
| B | ASP216 |
| B | SER217 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 272 |
| Chain | Residue |
| A | MET19 |
| A | HIS23 |
| A | ARG31 |
| A | HOH360 |
| A | HOH504 |
| B | LYS183 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 273 |
| Chain | Residue |
| A | LYS116 |
| A | LYS117 |
| A | THR119 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 274 |
| site_id | BC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 3TJ B 400 |
| Chain | Residue |
| A | LYS104 |
| A | PRO105 |
| A | PHE106 |
| A | MET107 |
| A | SER108 |
| A | SER242 |
| B | ILE92 |
| B | PRO105 |
| B | MET107 |
| B | SER108 |
| B | SER217 |
| B | LYS218 |
| B | GLY219 |
| B | 3TJ265 |
| site_id | BC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 3TJ B 265 |
| Chain | Residue |
| A | ILE92 |
| A | PRO105 |
| A | SER108 |
| A | SER217 |
| A | LYS218 |
| A | GLY219 |
| A | HOH428 |
| B | LYS104 |
| B | PRO105 |
| B | PHE106 |
| B | MET107 |
| B | SER108 |
| B | SER242 |
| B | 3TJ400 |
| site_id | BC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GLU B 399 |
| Chain | Residue |
| B | TYR61 |
| B | PRO89 |
| B | LEU90 |
| B | THR91 |
| B | ARG96 |
| B | LEU138 |
| B | GLY141 |
| B | SER142 |
| B | THR143 |
| B | GLU193 |
| B | HOH277 |
| B | HOH281 |
| B | HOH319 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 266 |
| Chain | Residue |
| B | SER140 |
| B | LYS144 |
| B | ARG148 |
| B | HOH315 |
| B | HOH356 |
| B | HOH438 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 267 |
| Chain | Residue |
| B | ARG148 |
| B | TRP159 |
| B | ARG163 |
| B | HOH540 |
| site_id | BC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 268 |
| Chain | Residue |
| B | GLY62 |
| B | ALA63 |
| B | TRP71 |
| B | THR93 |
| B | ARG96 |
| B | GLU145 |
| B | HOH315 |
| B | HOH426 |
| B | HOH439 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 269 |
| Chain | Residue |
| B | SER108 |
| B | SER194 |
| B | GLU198 |
| B | ASN214 |
| B | HOH361 |
| B | HOH410 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 270 |
| Chain | Residue |
| A | LYS258 |
| B | HIS23 |
| B | ARG31 |
| B | HOH341 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 271 |
| Chain | Residue |
| B | GLU27 |
| B | GLY28 |
| B | ARG31 |
| B | LYS52 |
| B | HOH371 |
| site_id | CC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 272 |
| Chain | Residue |
| B | LYS116 |
| B | LYS185 |
| B | HOH374 |
| site_id | CC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 273 |
| Chain | Residue |
| B | LYS4 |
| B | THR5 |
| B | HOH465 |
| site_id | CC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 274 |
| Chain | Residue |
| B | LYS82 |
| B | LYS116 |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | PRO89 | |
| B | SER142 | |
| B | THR143 | |
| B | GLU193 | |
| A | THR91 | |
| A | ARG96 | |
| A | SER142 | |
| A | THR143 | |
| A | GLU193 | |
| B | PRO89 | |
| B | THR91 | |
| B | ARG96 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| A | ARG64 | |
| A | ARG148 | |
| A | LYS240 | |
| B | ARG64 | |
| B | ARG148 | |
| B | LYS240 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| A | ILE121 | |
| B | ILE121 | |
| Chain | Residue | Details |
| A | SER150 | |
| B | SER150 | |
| Chain | Residue | Details |
| A | SER184 | |
| B | SER184 | |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN3 | |
| B | ASN3 | |
