3SRF

Human M1 pyruvate kinase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	C, A, B, D, E...	Pyruvate kinase isozymes M1/M2	polymer	551	60314.5	8	UniProt (P14618) Pfam (PF00224) Pfam (PF02887) In PDB	Homo sapiens (human)	Cytosolic thyroid hormone-binding protein, CTHBP, Opa-interacting protein 3, OIP-3, Pyruvate kinase 2/3, Pyruvate kinase muscle isozyme, Thyroid hormone-binding protein 1, THBP1, Tumor M2-PK, p58
2	E, F, C, A, G...	PHOSPHATE ION	non-polymer		95.0	8	Chemie (PO4)
3	E, F, C, A, G...	POTASSIUM ION	non-polymer		39.1	8	Chemie (K)
4	E, F, C, A, G...	MAGNESIUM ION	non-polymer		24.3	8	Chemie (MG)
5	D, E, F, C, A...	PYRUVIC ACID	non-polymer		88.1	8	Chemie (PYR)
6	D, E, F, C, A...	GLYCEROL	non-polymer		92.1	8	Chemie (GOL)
7		water	water		18.0	478	Chemie (HOH)

Sequence modifications

C, A, B, D, E, F, G, H: 0 - 530 (UniProt: P14618)

PDB	External Database	Details
Met -20	-	expression tag
Gly -19	-	expression tag
Ser -18	-	expression tag
Ser -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Leu -7	-	expression tag
Val -6	-	expression tag
Pro -5	-	expression tag
Arg -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
His -1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	482515.7
Non-Polymers*	Number of molecules	40
	Total formula weight	2708.2
All*	Total formula weight	485223.9

*Water molecules are not included.