3SRF

Human M1 pyruvate kinase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0003723	molecular_function	RNA binding
A	0003729	molecular_function	mRNA binding
A	0003824	molecular_function	catalytic activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
A	0004743	molecular_function	pyruvate kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005791	cellular_component	rough endoplasmic reticulum
A	0005829	cellular_component	cytosol
A	0005929	cellular_component	cilium
A	0006096	biological_process	glycolytic process
A	0006417	biological_process	regulation of translation
A	0012501	biological_process	programmed cell death
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0023026	molecular_function	MHC class II protein complex binding
A	0030955	molecular_function	potassium ion binding
A	0031982	cellular_component	vesicle
A	0032869	biological_process	cellular response to insulin stimulus
A	0034774	cellular_component	secretory granule lumen
A	0045296	molecular_function	cadherin binding
A	0046872	molecular_function	metal ion binding
A	0061621	biological_process	canonical glycolysis
A	0070062	cellular_component	extracellular exosome
A	0097228	cellular_component	sperm principal piece
A	1903561	cellular_component	extracellular vesicle
A	1903672	biological_process	positive regulation of sprouting angiogenesis
A	1904813	cellular_component	ficolin-1-rich granule lumen
A	2000767	biological_process	positive regulation of cytoplasmic translation
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0003723	molecular_function	RNA binding
B	0003729	molecular_function	mRNA binding
B	0003824	molecular_function	catalytic activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
B	0004743	molecular_function	pyruvate kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005791	cellular_component	rough endoplasmic reticulum
B	0005829	cellular_component	cytosol
B	0005929	cellular_component	cilium
B	0006096	biological_process	glycolytic process
B	0006417	biological_process	regulation of translation
B	0012501	biological_process	programmed cell death
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0023026	molecular_function	MHC class II protein complex binding
B	0030955	molecular_function	potassium ion binding
B	0031982	cellular_component	vesicle
B	0032869	biological_process	cellular response to insulin stimulus
B	0034774	cellular_component	secretory granule lumen
B	0045296	molecular_function	cadherin binding
B	0046872	molecular_function	metal ion binding
B	0061621	biological_process	canonical glycolysis
B	0070062	cellular_component	extracellular exosome
B	0097228	cellular_component	sperm principal piece
B	1903561	cellular_component	extracellular vesicle
B	1903672	biological_process	positive regulation of sprouting angiogenesis
B	1904813	cellular_component	ficolin-1-rich granule lumen
B	2000767	biological_process	positive regulation of cytoplasmic translation
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0003723	molecular_function	RNA binding
C	0003729	molecular_function	mRNA binding
C	0003824	molecular_function	catalytic activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
C	0004743	molecular_function	pyruvate kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005791	cellular_component	rough endoplasmic reticulum
C	0005829	cellular_component	cytosol
C	0005929	cellular_component	cilium
C	0006096	biological_process	glycolytic process
C	0006417	biological_process	regulation of translation
C	0012501	biological_process	programmed cell death
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0023026	molecular_function	MHC class II protein complex binding
C	0030955	molecular_function	potassium ion binding
C	0031982	cellular_component	vesicle
C	0032869	biological_process	cellular response to insulin stimulus
C	0034774	cellular_component	secretory granule lumen
C	0045296	molecular_function	cadherin binding
C	0046872	molecular_function	metal ion binding
C	0061621	biological_process	canonical glycolysis
C	0070062	cellular_component	extracellular exosome
C	0097228	cellular_component	sperm principal piece
C	1903561	cellular_component	extracellular vesicle
C	1903672	biological_process	positive regulation of sprouting angiogenesis
C	1904813	cellular_component	ficolin-1-rich granule lumen
C	2000767	biological_process	positive regulation of cytoplasmic translation
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0003723	molecular_function	RNA binding
D	0003729	molecular_function	mRNA binding
D	0003824	molecular_function	catalytic activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0004713	molecular_function	protein tyrosine kinase activity
D	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
D	0004743	molecular_function	pyruvate kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005791	cellular_component	rough endoplasmic reticulum
D	0005829	cellular_component	cytosol
D	0005929	cellular_component	cilium
D	0006096	biological_process	glycolytic process
D	0006417	biological_process	regulation of translation
D	0012501	biological_process	programmed cell death
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0023026	molecular_function	MHC class II protein complex binding
D	0030955	molecular_function	potassium ion binding
D	0031982	cellular_component	vesicle
D	0032869	biological_process	cellular response to insulin stimulus
D	0034774	cellular_component	secretory granule lumen
D	0045296	molecular_function	cadherin binding
D	0046872	molecular_function	metal ion binding
D	0061621	biological_process	canonical glycolysis
D	0070062	cellular_component	extracellular exosome
D	0097228	cellular_component	sperm principal piece
D	1903561	cellular_component	extracellular vesicle
D	1903672	biological_process	positive regulation of sprouting angiogenesis
D	1904813	cellular_component	ficolin-1-rich granule lumen
D	2000767	biological_process	positive regulation of cytoplasmic translation
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0003723	molecular_function	RNA binding
E	0003729	molecular_function	mRNA binding
E	0003824	molecular_function	catalytic activity
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0004713	molecular_function	protein tyrosine kinase activity
E	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
E	0004743	molecular_function	pyruvate kinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005791	cellular_component	rough endoplasmic reticulum
E	0005829	cellular_component	cytosol
E	0005929	cellular_component	cilium
E	0006096	biological_process	glycolytic process
E	0006417	biological_process	regulation of translation
E	0012501	biological_process	programmed cell death
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0023026	molecular_function	MHC class II protein complex binding
E	0030955	molecular_function	potassium ion binding
E	0031982	cellular_component	vesicle
E	0032869	biological_process	cellular response to insulin stimulus
E	0034774	cellular_component	secretory granule lumen
E	0045296	molecular_function	cadherin binding
E	0046872	molecular_function	metal ion binding
E	0061621	biological_process	canonical glycolysis
E	0070062	cellular_component	extracellular exosome
E	0097228	cellular_component	sperm principal piece
E	1903561	cellular_component	extracellular vesicle
E	1903672	biological_process	positive regulation of sprouting angiogenesis
E	1904813	cellular_component	ficolin-1-rich granule lumen
E	2000767	biological_process	positive regulation of cytoplasmic translation
F	0000166	molecular_function	nucleotide binding
F	0000287	molecular_function	magnesium ion binding
F	0003723	molecular_function	RNA binding
F	0003729	molecular_function	mRNA binding
F	0003824	molecular_function	catalytic activity
F	0004674	molecular_function	protein serine/threonine kinase activity
F	0004713	molecular_function	protein tyrosine kinase activity
F	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
F	0004743	molecular_function	pyruvate kinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005791	cellular_component	rough endoplasmic reticulum
F	0005829	cellular_component	cytosol
F	0005929	cellular_component	cilium
F	0006096	biological_process	glycolytic process
F	0006417	biological_process	regulation of translation
F	0012501	biological_process	programmed cell death
F	0016301	molecular_function	kinase activity
F	0016740	molecular_function	transferase activity
F	0023026	molecular_function	MHC class II protein complex binding
F	0030955	molecular_function	potassium ion binding
F	0031982	cellular_component	vesicle
F	0032869	biological_process	cellular response to insulin stimulus
F	0034774	cellular_component	secretory granule lumen
F	0045296	molecular_function	cadherin binding
F	0046872	molecular_function	metal ion binding
F	0061621	biological_process	canonical glycolysis
F	0070062	cellular_component	extracellular exosome
F	0097228	cellular_component	sperm principal piece
F	1903561	cellular_component	extracellular vesicle
F	1903672	biological_process	positive regulation of sprouting angiogenesis
F	1904813	cellular_component	ficolin-1-rich granule lumen
F	2000767	biological_process	positive regulation of cytoplasmic translation
G	0000166	molecular_function	nucleotide binding
G	0000287	molecular_function	magnesium ion binding
G	0003723	molecular_function	RNA binding
G	0003729	molecular_function	mRNA binding
G	0003824	molecular_function	catalytic activity
G	0004674	molecular_function	protein serine/threonine kinase activity
G	0004713	molecular_function	protein tyrosine kinase activity
G	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
G	0004743	molecular_function	pyruvate kinase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005791	cellular_component	rough endoplasmic reticulum
G	0005829	cellular_component	cytosol
G	0005929	cellular_component	cilium
G	0006096	biological_process	glycolytic process
G	0006417	biological_process	regulation of translation
G	0012501	biological_process	programmed cell death
G	0016301	molecular_function	kinase activity
G	0016740	molecular_function	transferase activity
G	0023026	molecular_function	MHC class II protein complex binding
G	0030955	molecular_function	potassium ion binding
G	0031982	cellular_component	vesicle
G	0032869	biological_process	cellular response to insulin stimulus
G	0034774	cellular_component	secretory granule lumen
G	0045296	molecular_function	cadherin binding
G	0046872	molecular_function	metal ion binding
G	0061621	biological_process	canonical glycolysis
G	0070062	cellular_component	extracellular exosome
G	0097228	cellular_component	sperm principal piece
G	1903561	cellular_component	extracellular vesicle
G	1903672	biological_process	positive regulation of sprouting angiogenesis
G	1904813	cellular_component	ficolin-1-rich granule lumen
G	2000767	biological_process	positive regulation of cytoplasmic translation
H	0000166	molecular_function	nucleotide binding
H	0000287	molecular_function	magnesium ion binding
H	0003723	molecular_function	RNA binding
H	0003729	molecular_function	mRNA binding
H	0003824	molecular_function	catalytic activity
H	0004674	molecular_function	protein serine/threonine kinase activity
H	0004713	molecular_function	protein tyrosine kinase activity
H	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
H	0004743	molecular_function	pyruvate kinase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005791	cellular_component	rough endoplasmic reticulum
H	0005829	cellular_component	cytosol
H	0005929	cellular_component	cilium
H	0006096	biological_process	glycolytic process
H	0006417	biological_process	regulation of translation
H	0012501	biological_process	programmed cell death
H	0016301	molecular_function	kinase activity
H	0016740	molecular_function	transferase activity
H	0023026	molecular_function	MHC class II protein complex binding
H	0030955	molecular_function	potassium ion binding
H	0031982	cellular_component	vesicle
H	0032869	biological_process	cellular response to insulin stimulus
H	0034774	cellular_component	secretory granule lumen
H	0045296	molecular_function	cadherin binding
H	0046872	molecular_function	metal ion binding
H	0061621	biological_process	canonical glycolysis
H	0070062	cellular_component	extracellular exosome
H	0097228	cellular_component	sperm principal piece
H	1903561	cellular_component	extracellular vesicle
H	1903672	biological_process	positive regulation of sprouting angiogenesis
H	1904813	cellular_component	ficolin-1-rich granule lumen
H	2000767	biological_process	positive regulation of cytoplasmic translation

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 C 531

Chain	Residue
C	THR431
C	GLU432
C	SER433
C	GLY434
C	ARG435
C	SER436
C	GLY519

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K C 532

Chain	Residue
C	ASP112
C	THR113
C	SER242
C	LYS269
C	ASN74
C	SER76

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG C 533

Chain	Residue
C	GLU271
C	ASP295
C	PYR534

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PYR C 534

Chain	Residue
C	ARG72
C	LYS269
C	GLU271
C	MET290
C	ALA292
C	GLY294
C	ASP295
C	THR327
C	SER361
C	MG533

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 535

Chain	Residue
C	ARG42
C	ASN43
C	HIS463
C	TYR465
C	ILE468
C	PHE469

---

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 A 531

Chain	Residue
A	THR431
A	GLU432
A	SER433
A	GLY434
A	ARG435
A	SER436
A	GLY519
A	HOH568
A	HOH591

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 532

Chain	Residue
A	ASN74
A	SER76
A	ASP112
A	THR113
A	HOH551
A	HOH594

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 533

Chain	Residue
A	GLU271
A	ASP295
A	PYR534

---

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PYR A 534

Chain	Residue
A	LYS269
A	GLU271
A	ALA292
A	ARG293
A	GLY294
A	ASP295
A	THR327
A	MG533
A	HOH594

---

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 535

Chain	Residue
A	ARG42
A	ASN43
A	GLY45
A	ASN69
A	HIS463
A	ILE468
A	PHE469
A	PRO470

---

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 B 531

Chain	Residue
B	THR431
B	GLU432
B	SER433
B	GLY434
B	ARG435
B	SER436
B	GLY519
B	PHE520

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K B 532

Chain	Residue
B	ASN74
B	SER76
B	ASP112
B	THR113
B	LYS269

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG B 533

Chain	Residue
B	GLU271
B	ASP295
B	PYR534

---

site_id	BC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PYR B 534

Chain	Residue
B	LYS269
B	GLU271
B	MET290
B	ALA292
B	GLY294
B	ASP295
B	THR327
B	MG533

---

site_id	BC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL B 535

Chain	Residue
B	ARG42
B	ASN43
B	THR44
B	GLY45
B	ASN69
B	HIS463
B	ILE468
B	PHE469

---

site_id	BC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 D 531

Chain	Residue
D	LEU430
D	THR431
D	GLU432
D	SER433
D	GLY434
D	ARG435
D	SER436
D	GLY519

---

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K D 532

Chain	Residue
D	ASN74
D	SER76
D	ASP112
D	THR113
D	LYS269
D	HOH556

---

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG D 533

Chain	Residue
D	GLU271
D	ASP295
D	PYR534
D	HOH556

---

site_id	CC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PYR D 534

Chain	Residue
D	LYS269
D	GLU271
D	ALA292
D	GLY294
D	ASP295
D	THR327
D	MG533

---

site_id	CC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL D 535

Chain	Residue
D	ARG42
D	ASN43
D	GLY45
D	ASN69
D	HIS463
D	ILE468
D	PHE469

---

site_id	CC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 E 531

Chain	Residue
E	LEU430
E	THR431
E	GLU432
E	SER433
E	GLY434
E	ARG435
E	SER436
E	GLY519

---

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K E 532

Chain	Residue
E	ASN74
E	SER76
E	THR113
E	LYS269

---

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG E 533

Chain	Residue
E	LYS269
E	GLU271
E	ASP295
E	PYR534

---

site_id	CC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PYR E 534

Chain	Residue
E	LYS269
E	GLU271
E	ALA292
E	GLY294
E	ASP295
E	THR327
E	MG533

---

site_id	CC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL E 535

Chain	Residue
E	ARG42
E	ASN43
E	THR44
E	GLY45
E	ASN69
E	HIS463
E	ILE468
E	PHE469

---

site_id	CC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 F 531

Chain	Residue
F	THR431
F	GLU432
F	SER433
F	GLY434
F	ARG435
F	SER436
F	GLY519
F	PHE520
F	HOH578

---

site_id	CC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K F 532

Chain	Residue
F	ASN74
F	SER76
F	ASP112
F	THR113
F	LYS269
F	HOH581

---

site_id	DC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG F 533

Chain	Residue
F	GLU271
F	ASP295
F	PYR534

---

site_id	DC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PYR F 534

Chain	Residue
F	LYS269
F	GLU271
F	ALA292
F	GLY294
F	ASP295
F	THR327
F	MG533

---

site_id	DC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL F 535

Chain	Residue
F	PRO116
F	ASN209
F	LEU210
F	VAL215
F	GLU299

---

site_id	DC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL F 536

Chain	Residue
F	ARG42
F	ASN43
F	GLY45
F	ASN69
F	HIS463
F	TYR465
F	ILE468
F	PHE469

---

site_id	DC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 G 531

Chain	Residue
G	LEU430
G	THR431
G	GLU432
G	SER433
G	GLY434
G	ARG435
G	SER436
G	GLY519

---

site_id	DC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K G 532

Chain	Residue
G	ASN74
G	SER76
G	ASP112
G	THR113
G	SER242
G	LYS269
G	HOH585

---

site_id	DC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG G 533

Chain	Residue
G	GLU271
G	ASP295
G	PYR534
G	HOH584

---

site_id	DC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PYR G 534

Chain	Residue
G	ARG72
G	LYS269
G	GLU271
G	ALA292
G	GLY294
G	ASP295
G	THR327
G	MG533
G	HOH585

---

site_id	DC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL G 535

Chain	Residue
G	ARG42
G	ASN43
G	GLY45
G	ASN69
G	HIS463
G	TYR465
G	ILE468
G	PHE469

---

site_id	EC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 H 531

Chain	Residue
H	THR431
H	GLU432
H	SER433
H	ARG435
H	SER436

---

site_id	EC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K H 532

Chain	Residue
H	ASN74
H	SER76
H	ASP112
H	THR113
H	LYS269

---

site_id	EC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG H 533

Chain	Residue
H	LYS269
H	GLU271
H	ASP295
H	PYR534

---

site_id	EC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PYR H 534

Chain	Residue
H	MET290
H	ALA292
H	GLY294
H	ASP295
H	THR327
H	MG533

---

Functional Information from PROSITE/UniProt

site_id	PS00110
Number of Residues	13
Details	PYRUVATE_KINASE Pyruvate kinase active site signature. IkIISKIENhEGV

Chain	Residue	Details
C	ILE264-VAL276

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1792
Details	Region: {"description":"Interaction with POU5F1","evidences":[{"source":"PubMed","id":"18191611","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	352
Details	Region: {"description":"Intersubunit contact"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23064226","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P30613","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	80
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23530218","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FXF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	96
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15996096","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23530218","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FXF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"P00549","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Site: {"description":"Crucial for phosphotyrosine binding","evidences":[{"source":"PubMed","id":"27199445","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18088087","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	16
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	16
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P52480","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	16
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P11980","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	8
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	8
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P52480","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	16
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P52480","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	8
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P52480","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"21700219","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	16
Details	Modified residue: {"description":"4-hydroxyproline","evidences":[{"source":"PubMed","id":"21620138","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	16
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"30487609","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"24120661","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26787900","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P52480","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	24
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---