3SRF
Human M1 pyruvate kinase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003729 | molecular_function | mRNA binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0004743 | molecular_function | pyruvate kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005791 | cellular_component | rough endoplasmic reticulum |
| A | 0005829 | cellular_component | cytosol |
| A | 0005929 | cellular_component | cilium |
| A | 0006096 | biological_process | glycolytic process |
| A | 0006417 | biological_process | regulation of translation |
| A | 0012501 | biological_process | programmed cell death |
| A | 0016301 | molecular_function | kinase activity |
| A | 0023026 | molecular_function | MHC class II protein complex binding |
| A | 0030955 | molecular_function | potassium ion binding |
| A | 0031982 | cellular_component | vesicle |
| A | 0032869 | biological_process | cellular response to insulin stimulus |
| A | 0034774 | cellular_component | secretory granule lumen |
| A | 0045296 | molecular_function | cadherin binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0061621 | biological_process | canonical glycolysis |
| A | 0062023 | cellular_component | collagen-containing extracellular matrix |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 1903561 | cellular_component | extracellular vesicle |
| A | 1903672 | biological_process | positive regulation of sprouting angiogenesis |
| A | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| A | 2000767 | biological_process | positive regulation of cytoplasmic translation |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003729 | molecular_function | mRNA binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004713 | molecular_function | protein tyrosine kinase activity |
| B | 0004743 | molecular_function | pyruvate kinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005791 | cellular_component | rough endoplasmic reticulum |
| B | 0005829 | cellular_component | cytosol |
| B | 0005929 | cellular_component | cilium |
| B | 0006096 | biological_process | glycolytic process |
| B | 0006417 | biological_process | regulation of translation |
| B | 0012501 | biological_process | programmed cell death |
| B | 0016301 | molecular_function | kinase activity |
| B | 0023026 | molecular_function | MHC class II protein complex binding |
| B | 0030955 | molecular_function | potassium ion binding |
| B | 0031982 | cellular_component | vesicle |
| B | 0032869 | biological_process | cellular response to insulin stimulus |
| B | 0034774 | cellular_component | secretory granule lumen |
| B | 0045296 | molecular_function | cadherin binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0061621 | biological_process | canonical glycolysis |
| B | 0062023 | cellular_component | collagen-containing extracellular matrix |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 1903561 | cellular_component | extracellular vesicle |
| B | 1903672 | biological_process | positive regulation of sprouting angiogenesis |
| B | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| B | 2000767 | biological_process | positive regulation of cytoplasmic translation |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0003723 | molecular_function | RNA binding |
| C | 0003729 | molecular_function | mRNA binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004713 | molecular_function | protein tyrosine kinase activity |
| C | 0004743 | molecular_function | pyruvate kinase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005791 | cellular_component | rough endoplasmic reticulum |
| C | 0005829 | cellular_component | cytosol |
| C | 0005929 | cellular_component | cilium |
| C | 0006096 | biological_process | glycolytic process |
| C | 0006417 | biological_process | regulation of translation |
| C | 0012501 | biological_process | programmed cell death |
| C | 0016301 | molecular_function | kinase activity |
| C | 0023026 | molecular_function | MHC class II protein complex binding |
| C | 0030955 | molecular_function | potassium ion binding |
| C | 0031982 | cellular_component | vesicle |
| C | 0032869 | biological_process | cellular response to insulin stimulus |
| C | 0034774 | cellular_component | secretory granule lumen |
| C | 0045296 | molecular_function | cadherin binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0061621 | biological_process | canonical glycolysis |
| C | 0062023 | cellular_component | collagen-containing extracellular matrix |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 1903561 | cellular_component | extracellular vesicle |
| C | 1903672 | biological_process | positive regulation of sprouting angiogenesis |
| C | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| C | 2000767 | biological_process | positive regulation of cytoplasmic translation |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0003723 | molecular_function | RNA binding |
| D | 0003729 | molecular_function | mRNA binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004713 | molecular_function | protein tyrosine kinase activity |
| D | 0004743 | molecular_function | pyruvate kinase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005791 | cellular_component | rough endoplasmic reticulum |
| D | 0005829 | cellular_component | cytosol |
| D | 0005929 | cellular_component | cilium |
| D | 0006096 | biological_process | glycolytic process |
| D | 0006417 | biological_process | regulation of translation |
| D | 0012501 | biological_process | programmed cell death |
| D | 0016301 | molecular_function | kinase activity |
| D | 0023026 | molecular_function | MHC class II protein complex binding |
| D | 0030955 | molecular_function | potassium ion binding |
| D | 0031982 | cellular_component | vesicle |
| D | 0032869 | biological_process | cellular response to insulin stimulus |
| D | 0034774 | cellular_component | secretory granule lumen |
| D | 0045296 | molecular_function | cadherin binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0061621 | biological_process | canonical glycolysis |
| D | 0062023 | cellular_component | collagen-containing extracellular matrix |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 1903561 | cellular_component | extracellular vesicle |
| D | 1903672 | biological_process | positive regulation of sprouting angiogenesis |
| D | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| D | 2000767 | biological_process | positive regulation of cytoplasmic translation |
| E | 0000287 | molecular_function | magnesium ion binding |
| E | 0003723 | molecular_function | RNA binding |
| E | 0003729 | molecular_function | mRNA binding |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004713 | molecular_function | protein tyrosine kinase activity |
| E | 0004743 | molecular_function | pyruvate kinase activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005576 | cellular_component | extracellular region |
| E | 0005634 | cellular_component | nucleus |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005739 | cellular_component | mitochondrion |
| E | 0005791 | cellular_component | rough endoplasmic reticulum |
| E | 0005829 | cellular_component | cytosol |
| E | 0005929 | cellular_component | cilium |
| E | 0006096 | biological_process | glycolytic process |
| E | 0006417 | biological_process | regulation of translation |
| E | 0012501 | biological_process | programmed cell death |
| E | 0016301 | molecular_function | kinase activity |
| E | 0023026 | molecular_function | MHC class II protein complex binding |
| E | 0030955 | molecular_function | potassium ion binding |
| E | 0031982 | cellular_component | vesicle |
| E | 0032869 | biological_process | cellular response to insulin stimulus |
| E | 0034774 | cellular_component | secretory granule lumen |
| E | 0045296 | molecular_function | cadherin binding |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0061621 | biological_process | canonical glycolysis |
| E | 0062023 | cellular_component | collagen-containing extracellular matrix |
| E | 0070062 | cellular_component | extracellular exosome |
| E | 1903561 | cellular_component | extracellular vesicle |
| E | 1903672 | biological_process | positive regulation of sprouting angiogenesis |
| E | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| E | 2000767 | biological_process | positive regulation of cytoplasmic translation |
| F | 0000287 | molecular_function | magnesium ion binding |
| F | 0003723 | molecular_function | RNA binding |
| F | 0003729 | molecular_function | mRNA binding |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004713 | molecular_function | protein tyrosine kinase activity |
| F | 0004743 | molecular_function | pyruvate kinase activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005524 | molecular_function | ATP binding |
| F | 0005576 | cellular_component | extracellular region |
| F | 0005634 | cellular_component | nucleus |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005739 | cellular_component | mitochondrion |
| F | 0005791 | cellular_component | rough endoplasmic reticulum |
| F | 0005829 | cellular_component | cytosol |
| F | 0005929 | cellular_component | cilium |
| F | 0006096 | biological_process | glycolytic process |
| F | 0006417 | biological_process | regulation of translation |
| F | 0012501 | biological_process | programmed cell death |
| F | 0016301 | molecular_function | kinase activity |
| F | 0023026 | molecular_function | MHC class II protein complex binding |
| F | 0030955 | molecular_function | potassium ion binding |
| F | 0031982 | cellular_component | vesicle |
| F | 0032869 | biological_process | cellular response to insulin stimulus |
| F | 0034774 | cellular_component | secretory granule lumen |
| F | 0045296 | molecular_function | cadherin binding |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0061621 | biological_process | canonical glycolysis |
| F | 0062023 | cellular_component | collagen-containing extracellular matrix |
| F | 0070062 | cellular_component | extracellular exosome |
| F | 1903561 | cellular_component | extracellular vesicle |
| F | 1903672 | biological_process | positive regulation of sprouting angiogenesis |
| F | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| F | 2000767 | biological_process | positive regulation of cytoplasmic translation |
| G | 0000287 | molecular_function | magnesium ion binding |
| G | 0003723 | molecular_function | RNA binding |
| G | 0003729 | molecular_function | mRNA binding |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0004713 | molecular_function | protein tyrosine kinase activity |
| G | 0004743 | molecular_function | pyruvate kinase activity |
| G | 0005515 | molecular_function | protein binding |
| G | 0005524 | molecular_function | ATP binding |
| G | 0005576 | cellular_component | extracellular region |
| G | 0005634 | cellular_component | nucleus |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005739 | cellular_component | mitochondrion |
| G | 0005791 | cellular_component | rough endoplasmic reticulum |
| G | 0005829 | cellular_component | cytosol |
| G | 0005929 | cellular_component | cilium |
| G | 0006096 | biological_process | glycolytic process |
| G | 0006417 | biological_process | regulation of translation |
| G | 0012501 | biological_process | programmed cell death |
| G | 0016301 | molecular_function | kinase activity |
| G | 0023026 | molecular_function | MHC class II protein complex binding |
| G | 0030955 | molecular_function | potassium ion binding |
| G | 0031982 | cellular_component | vesicle |
| G | 0032869 | biological_process | cellular response to insulin stimulus |
| G | 0034774 | cellular_component | secretory granule lumen |
| G | 0045296 | molecular_function | cadherin binding |
| G | 0046872 | molecular_function | metal ion binding |
| G | 0061621 | biological_process | canonical glycolysis |
| G | 0062023 | cellular_component | collagen-containing extracellular matrix |
| G | 0070062 | cellular_component | extracellular exosome |
| G | 1903561 | cellular_component | extracellular vesicle |
| G | 1903672 | biological_process | positive regulation of sprouting angiogenesis |
| G | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| G | 2000767 | biological_process | positive regulation of cytoplasmic translation |
| H | 0000287 | molecular_function | magnesium ion binding |
| H | 0003723 | molecular_function | RNA binding |
| H | 0003729 | molecular_function | mRNA binding |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0004713 | molecular_function | protein tyrosine kinase activity |
| H | 0004743 | molecular_function | pyruvate kinase activity |
| H | 0005515 | molecular_function | protein binding |
| H | 0005524 | molecular_function | ATP binding |
| H | 0005576 | cellular_component | extracellular region |
| H | 0005634 | cellular_component | nucleus |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005739 | cellular_component | mitochondrion |
| H | 0005791 | cellular_component | rough endoplasmic reticulum |
| H | 0005829 | cellular_component | cytosol |
| H | 0005929 | cellular_component | cilium |
| H | 0006096 | biological_process | glycolytic process |
| H | 0006417 | biological_process | regulation of translation |
| H | 0012501 | biological_process | programmed cell death |
| H | 0016301 | molecular_function | kinase activity |
| H | 0023026 | molecular_function | MHC class II protein complex binding |
| H | 0030955 | molecular_function | potassium ion binding |
| H | 0031982 | cellular_component | vesicle |
| H | 0032869 | biological_process | cellular response to insulin stimulus |
| H | 0034774 | cellular_component | secretory granule lumen |
| H | 0045296 | molecular_function | cadherin binding |
| H | 0046872 | molecular_function | metal ion binding |
| H | 0061621 | biological_process | canonical glycolysis |
| H | 0062023 | cellular_component | collagen-containing extracellular matrix |
| H | 0070062 | cellular_component | extracellular exosome |
| H | 1903561 | cellular_component | extracellular vesicle |
| H | 1903672 | biological_process | positive regulation of sprouting angiogenesis |
| H | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| H | 2000767 | biological_process | positive regulation of cytoplasmic translation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 C 531 |
| Chain | Residue |
| C | THR431 |
| C | GLU432 |
| C | SER433 |
| C | GLY434 |
| C | ARG435 |
| C | SER436 |
| C | GLY519 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K C 532 |
| Chain | Residue |
| C | ASP112 |
| C | THR113 |
| C | SER242 |
| C | LYS269 |
| C | ASN74 |
| C | SER76 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG C 533 |
| Chain | Residue |
| C | GLU271 |
| C | ASP295 |
| C | PYR534 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PYR C 534 |
| Chain | Residue |
| C | ARG72 |
| C | LYS269 |
| C | GLU271 |
| C | MET290 |
| C | ALA292 |
| C | GLY294 |
| C | ASP295 |
| C | THR327 |
| C | SER361 |
| C | MG533 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL C 535 |
| Chain | Residue |
| C | ARG42 |
| C | ASN43 |
| C | HIS463 |
| C | TYR465 |
| C | ILE468 |
| C | PHE469 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 A 531 |
| Chain | Residue |
| A | THR431 |
| A | GLU432 |
| A | SER433 |
| A | GLY434 |
| A | ARG435 |
| A | SER436 |
| A | GLY519 |
| A | HOH568 |
| A | HOH591 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 532 |
| Chain | Residue |
| A | ASN74 |
| A | SER76 |
| A | ASP112 |
| A | THR113 |
| A | HOH551 |
| A | HOH594 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 533 |
| Chain | Residue |
| A | GLU271 |
| A | ASP295 |
| A | PYR534 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PYR A 534 |
| Chain | Residue |
| A | LYS269 |
| A | GLU271 |
| A | ALA292 |
| A | ARG293 |
| A | GLY294 |
| A | ASP295 |
| A | THR327 |
| A | MG533 |
| A | HOH594 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 535 |
| Chain | Residue |
| A | ARG42 |
| A | ASN43 |
| A | GLY45 |
| A | ASN69 |
| A | HIS463 |
| A | ILE468 |
| A | PHE469 |
| A | PRO470 |
| site_id | BC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 B 531 |
| Chain | Residue |
| B | THR431 |
| B | GLU432 |
| B | SER433 |
| B | GLY434 |
| B | ARG435 |
| B | SER436 |
| B | GLY519 |
| B | PHE520 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K B 532 |
| Chain | Residue |
| B | ASN74 |
| B | SER76 |
| B | ASP112 |
| B | THR113 |
| B | LYS269 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 533 |
| Chain | Residue |
| B | GLU271 |
| B | ASP295 |
| B | PYR534 |
| site_id | BC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PYR B 534 |
| Chain | Residue |
| B | LYS269 |
| B | GLU271 |
| B | MET290 |
| B | ALA292 |
| B | GLY294 |
| B | ASP295 |
| B | THR327 |
| B | MG533 |
| site_id | BC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 535 |
| Chain | Residue |
| B | ARG42 |
| B | ASN43 |
| B | THR44 |
| B | GLY45 |
| B | ASN69 |
| B | HIS463 |
| B | ILE468 |
| B | PHE469 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 D 531 |
| Chain | Residue |
| D | LEU430 |
| D | THR431 |
| D | GLU432 |
| D | SER433 |
| D | GLY434 |
| D | ARG435 |
| D | SER436 |
| D | GLY519 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K D 532 |
| Chain | Residue |
| D | ASN74 |
| D | SER76 |
| D | ASP112 |
| D | THR113 |
| D | LYS269 |
| D | HOH556 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG D 533 |
| Chain | Residue |
| D | GLU271 |
| D | ASP295 |
| D | PYR534 |
| D | HOH556 |
| site_id | CC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PYR D 534 |
| Chain | Residue |
| D | LYS269 |
| D | GLU271 |
| D | ALA292 |
| D | GLY294 |
| D | ASP295 |
| D | THR327 |
| D | MG533 |
| site_id | CC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL D 535 |
| Chain | Residue |
| D | ARG42 |
| D | ASN43 |
| D | GLY45 |
| D | ASN69 |
| D | HIS463 |
| D | ILE468 |
| D | PHE469 |
| site_id | CC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 E 531 |
| Chain | Residue |
| E | LEU430 |
| E | THR431 |
| E | GLU432 |
| E | SER433 |
| E | GLY434 |
| E | ARG435 |
| E | SER436 |
| E | GLY519 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K E 532 |
| Chain | Residue |
| E | ASN74 |
| E | SER76 |
| E | THR113 |
| E | LYS269 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG E 533 |
| Chain | Residue |
| E | LYS269 |
| E | GLU271 |
| E | ASP295 |
| E | PYR534 |
| site_id | CC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PYR E 534 |
| Chain | Residue |
| E | LYS269 |
| E | GLU271 |
| E | ALA292 |
| E | GLY294 |
| E | ASP295 |
| E | THR327 |
| E | MG533 |
| site_id | CC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL E 535 |
| Chain | Residue |
| E | ARG42 |
| E | ASN43 |
| E | THR44 |
| E | GLY45 |
| E | ASN69 |
| E | HIS463 |
| E | ILE468 |
| E | PHE469 |
| site_id | CC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 F 531 |
| Chain | Residue |
| F | THR431 |
| F | GLU432 |
| F | SER433 |
| F | GLY434 |
| F | ARG435 |
| F | SER436 |
| F | GLY519 |
| F | PHE520 |
| F | HOH578 |
| site_id | CC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K F 532 |
| Chain | Residue |
| F | ASN74 |
| F | SER76 |
| F | ASP112 |
| F | THR113 |
| F | LYS269 |
| F | HOH581 |
| site_id | DC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG F 533 |
| Chain | Residue |
| F | GLU271 |
| F | ASP295 |
| F | PYR534 |
| site_id | DC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PYR F 534 |
| Chain | Residue |
| F | LYS269 |
| F | GLU271 |
| F | ALA292 |
| F | GLY294 |
| F | ASP295 |
| F | THR327 |
| F | MG533 |
| site_id | DC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL F 535 |
| Chain | Residue |
| F | PRO116 |
| F | ASN209 |
| F | LEU210 |
| F | VAL215 |
| F | GLU299 |
| site_id | DC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL F 536 |
| Chain | Residue |
| F | ARG42 |
| F | ASN43 |
| F | GLY45 |
| F | ASN69 |
| F | HIS463 |
| F | TYR465 |
| F | ILE468 |
| F | PHE469 |
| site_id | DC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 G 531 |
| Chain | Residue |
| G | LEU430 |
| G | THR431 |
| G | GLU432 |
| G | SER433 |
| G | GLY434 |
| G | ARG435 |
| G | SER436 |
| G | GLY519 |
| site_id | DC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K G 532 |
| Chain | Residue |
| G | ASN74 |
| G | SER76 |
| G | ASP112 |
| G | THR113 |
| G | SER242 |
| G | LYS269 |
| G | HOH585 |
| site_id | DC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG G 533 |
| Chain | Residue |
| G | GLU271 |
| G | ASP295 |
| G | PYR534 |
| G | HOH584 |
| site_id | DC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PYR G 534 |
| Chain | Residue |
| G | ARG72 |
| G | LYS269 |
| G | GLU271 |
| G | ALA292 |
| G | GLY294 |
| G | ASP295 |
| G | THR327 |
| G | MG533 |
| G | HOH585 |
| site_id | DC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL G 535 |
| Chain | Residue |
| G | ARG42 |
| G | ASN43 |
| G | GLY45 |
| G | ASN69 |
| G | HIS463 |
| G | TYR465 |
| G | ILE468 |
| G | PHE469 |
| site_id | EC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 H 531 |
| Chain | Residue |
| H | THR431 |
| H | GLU432 |
| H | SER433 |
| H | ARG435 |
| H | SER436 |
| site_id | EC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K H 532 |
| Chain | Residue |
| H | ASN74 |
| H | SER76 |
| H | ASP112 |
| H | THR113 |
| H | LYS269 |
| site_id | EC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG H 533 |
| Chain | Residue |
| H | LYS269 |
| H | GLU271 |
| H | ASP295 |
| H | PYR534 |
| site_id | EC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PYR H 534 |
| Chain | Residue |
| H | MET290 |
| H | ALA292 |
| H | GLY294 |
| H | ASP295 |
| H | THR327 |
| H | MG533 |
Functional Information from PROSITE/UniProt
| site_id | PS00110 |
| Number of Residues | 13 |
| Details | PYRUVATE_KINASE Pyruvate kinase active site signature. IkIISKIENhEGV |
| Chain | Residue | Details |
| C | ILE264-VAL276 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23064226 |
| Chain | Residue | Details |
| C | ASN69 | |
| D | ASN69 | |
| D | ARG105 | |
| D | HIS463 | |
| E | ASN69 | |
| E | ARG105 | |
| E | HIS463 | |
| F | ASN69 | |
| F | ARG105 | |
| F | HIS463 | |
| G | ASN69 | |
| C | ARG105 | |
| G | ARG105 | |
| G | HIS463 | |
| H | ASN69 | |
| H | ARG105 | |
| H | HIS463 | |
| C | HIS463 | |
| A | ASN69 | |
| A | ARG105 | |
| A | HIS463 | |
| B | ASN69 | |
| B | ARG105 | |
| B | HIS463 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P30613 |
| Chain | Residue | Details |
| C | ARG72 | |
| A | THR327 | |
| B | ARG72 | |
| B | LYS269 | |
| B | GLY294 | |
| B | ASP295 | |
| B | THR327 | |
| D | ARG72 | |
| D | LYS269 | |
| D | GLY294 | |
| D | ASP295 | |
| C | LYS269 | |
| D | THR327 | |
| E | ARG72 | |
| E | LYS269 | |
| E | GLY294 | |
| E | ASP295 | |
| E | THR327 | |
| F | ARG72 | |
| F | LYS269 | |
| F | GLY294 | |
| F | ASP295 | |
| C | GLY294 | |
| F | THR327 | |
| G | ARG72 | |
| G | LYS269 | |
| G | GLY294 | |
| G | ASP295 | |
| G | THR327 | |
| H | ARG72 | |
| H | LYS269 | |
| H | GLY294 | |
| H | ASP295 | |
| C | ASP295 | |
| H | THR327 | |
| C | THR327 | |
| A | ARG72 | |
| A | LYS269 | |
| A | GLY294 | |
| A | ASP295 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 56 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23530218, ECO:0007744|PDB:4FXF |
| Chain | Residue | Details |
| C | ASN74 | |
| A | ASP112 | |
| A | THR113 | |
| A | ARG119 | |
| A | LYS206 | |
| A | GLU271 | |
| B | ASN74 | |
| B | SER76 | |
| B | ASP112 | |
| B | THR113 | |
| B | ARG119 | |
| C | SER76 | |
| B | LYS206 | |
| B | GLU271 | |
| D | ASN74 | |
| D | SER76 | |
| D | ASP112 | |
| D | THR113 | |
| D | ARG119 | |
| D | LYS206 | |
| D | GLU271 | |
| E | ASN74 | |
| C | ASP112 | |
| E | SER76 | |
| E | ASP112 | |
| E | THR113 | |
| E | ARG119 | |
| E | LYS206 | |
| E | GLU271 | |
| F | ASN74 | |
| F | SER76 | |
| F | ASP112 | |
| F | THR113 | |
| C | THR113 | |
| F | ARG119 | |
| F | LYS206 | |
| F | GLU271 | |
| G | ASN74 | |
| G | SER76 | |
| G | ASP112 | |
| G | THR113 | |
| G | ARG119 | |
| G | LYS206 | |
| G | GLU271 | |
| C | ARG119 | |
| H | ASN74 | |
| H | SER76 | |
| H | ASP112 | |
| H | THR113 | |
| H | ARG119 | |
| H | LYS206 | |
| H | GLU271 | |
| C | LYS206 | |
| C | GLU271 | |
| A | ASN74 | |
| A | SER76 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:23530218, ECO:0007744|PDB:1T5A, ECO:0007744|PDB:4FXF |
| Chain | Residue | Details |
| C | THR431 | |
| B | TRP481 | |
| B | ARG488 | |
| B | ARG515 | |
| D | THR431 | |
| D | TRP481 | |
| D | ARG488 | |
| D | ARG515 | |
| E | THR431 | |
| E | TRP481 | |
| E | ARG488 | |
| C | TRP481 | |
| E | ARG515 | |
| F | THR431 | |
| F | TRP481 | |
| F | ARG488 | |
| F | ARG515 | |
| G | THR431 | |
| G | TRP481 | |
| G | ARG488 | |
| G | ARG515 | |
| H | THR431 | |
| C | ARG488 | |
| H | TRP481 | |
| H | ARG488 | |
| H | ARG515 | |
| C | ARG515 | |
| A | THR431 | |
| A | TRP481 | |
| A | ARG488 | |
| A | ARG515 | |
| B | THR431 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | SITE: Transition state stabilizer => ECO:0000250|UniProtKB:P00549 |
| Chain | Residue | Details |
| C | LYS269 | |
| A | LYS269 | |
| B | LYS269 | |
| D | LYS269 | |
| E | LYS269 | |
| F | LYS269 | |
| G | LYS269 | |
| H | LYS269 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | SITE: Crucial for phosphotyrosine binding => ECO:0000269|PubMed:27199445 |
| Chain | Residue | Details |
| C | GLU432 | |
| A | GLU432 | |
| B | GLU432 | |
| D | GLU432 | |
| E | GLU432 | |
| F | GLU432 | |
| G | GLU432 | |
| H | GLU432 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | MOD_RES: N-acetylserine => ECO:0000269|Ref.11, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:25944712 |
| Chain | Residue | Details |
| C | SER1 | |
| A | SER1 | |
| B | SER1 | |
| D | SER1 | |
| E | SER1 | |
| F | SER1 | |
| G | SER1 | |
| H | SER1 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | MOD_RES: N6,N6,N6-trimethyllysine => ECO:0007744|PubMed:24129315 |
| Chain | Residue | Details |
| C | LYS2 | |
| A | LYS2 | |
| B | LYS2 | |
| D | LYS2 | |
| E | LYS2 | |
| F | LYS2 | |
| G | LYS2 | |
| H | LYS2 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18088087, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| C | SER36 | |
| A | SER36 | |
| B | SER36 | |
| D | SER36 | |
| E | SER36 | |
| F | SER36 | |
| G | SER36 | |
| H | SER36 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | THR40 | |
| A | THR40 | |
| B | THR40 | |
| D | THR40 | |
| E | THR40 | |
| F | THR40 | |
| G | THR40 | |
| H | THR40 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 16 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| C | LYS61 | |
| E | LYS88 | |
| F | LYS61 | |
| F | LYS88 | |
| G | LYS61 | |
| G | LYS88 | |
| H | LYS61 | |
| H | LYS88 | |
| C | LYS88 | |
| A | LYS61 | |
| A | LYS88 | |
| B | LYS61 | |
| B | LYS88 | |
| D | LYS61 | |
| D | LYS88 | |
| E | LYS61 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 16 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P52480 |
| Chain | Residue | Details |
| C | LYS65 | |
| E | LYS497 | |
| F | LYS65 | |
| F | LYS497 | |
| G | LYS65 | |
| G | LYS497 | |
| H | LYS65 | |
| H | LYS497 | |
| C | LYS497 | |
| A | LYS65 | |
| A | LYS497 | |
| B | LYS65 | |
| B | LYS497 | |
| D | LYS65 | |
| D | LYS497 | |
| E | LYS65 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 16 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P11980 |
| Chain | Residue | Details |
| C | SER96 | |
| E | SER99 | |
| F | SER96 | |
| F | SER99 | |
| G | SER96 | |
| G | SER99 | |
| H | SER96 | |
| H | SER99 | |
| C | SER99 | |
| A | SER96 | |
| A | SER99 | |
| B | SER96 | |
| B | SER99 | |
| D | SER96 | |
| D | SER99 | |
| E | SER96 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | TYR104 | |
| A | TYR104 | |
| B | TYR104 | |
| D | TYR104 | |
| E | TYR104 | |
| F | TYR104 | |
| G | TYR104 | |
| H | TYR104 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | SER126 | |
| A | SER126 | |
| B | SER126 | |
| D | SER126 | |
| E | SER126 | |
| F | SER126 | |
| G | SER126 | |
| H | SER126 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P52480 |
| Chain | Residue | Details |
| C | TYR147 | |
| A | TYR147 | |
| B | TYR147 | |
| D | TYR147 | |
| E | TYR147 | |
| F | TYR147 | |
| G | TYR147 | |
| H | TYR147 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 16 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P52480 |
| Chain | Residue | Details |
| C | LYS165 | |
| E | LYS321 | |
| F | LYS165 | |
| F | LYS321 | |
| G | LYS165 | |
| G | LYS321 | |
| H | LYS165 | |
| H | LYS321 | |
| C | LYS321 | |
| A | LYS165 | |
| A | LYS321 | |
| B | LYS165 | |
| B | LYS321 | |
| D | LYS165 | |
| D | LYS321 | |
| E | LYS165 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| C | TYR174 | |
| A | TYR174 | |
| B | TYR174 | |
| D | TYR174 | |
| E | TYR174 | |
| F | TYR174 | |
| G | TYR174 | |
| H | TYR174 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| C | THR194 | |
| A | THR194 | |
| B | THR194 | |
| D | THR194 | |
| E | THR194 | |
| F | THR194 | |
| G | THR194 | |
| H | THR194 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| C | LYS265 | |
| A | LYS265 | |
| B | LYS265 | |
| D | LYS265 | |
| E | LYS265 | |
| F | LYS265 | |
| G | LYS265 | |
| H | LYS265 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P52480 |
| Chain | Residue | Details |
| C | LYS269 | |
| A | LYS269 | |
| B | LYS269 | |
| D | LYS269 | |
| E | LYS269 | |
| F | LYS269 | |
| G | LYS269 | |
| H | LYS269 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:21700219 |
| Chain | Residue | Details |
| C | LYS304 | |
| A | LYS304 | |
| B | LYS304 | |
| D | LYS304 | |
| E | LYS304 | |
| F | LYS304 | |
| G | LYS304 | |
| H | LYS304 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 16 |
| Details | MOD_RES: 4-hydroxyproline => ECO:0000269|PubMed:21620138 |
| Chain | Residue | Details |
| C | SER402 | |
| E | LEU407 | |
| F | SER402 | |
| F | LEU407 | |
| G | SER402 | |
| G | LEU407 | |
| H | SER402 | |
| H | LEU407 | |
| C | LEU407 | |
| A | SER402 | |
| A | LEU407 | |
| B | SER402 | |
| B | LEU407 | |
| D | SER402 | |
| D | LEU407 | |
| E | SER402 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 16 |
| Details | MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:30487609 |
| Chain | Residue | Details |
| C | CYS422 | |
| E | LEU423 | |
| F | CYS422 | |
| F | LEU423 | |
| G | CYS422 | |
| G | LEU423 | |
| H | CYS422 | |
| H | LEU423 | |
| C | LEU423 | |
| A | CYS422 | |
| A | LEU423 | |
| B | CYS422 | |
| B | LEU423 | |
| D | CYS422 | |
| D | LEU423 | |
| E | CYS422 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900, ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| C | GLU432 | |
| A | GLU432 | |
| B | GLU432 | |
| D | GLU432 | |
| E | GLU432 | |
| F | GLU432 | |
| G | GLU432 | |
| H | GLU432 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P52480 |
| Chain | Residue | Details |
| C | LYS474 | |
| A | LYS474 | |
| B | LYS474 | |
| D | LYS474 | |
| E | LYS474 | |
| F | LYS474 | |
| G | LYS474 | |
| H | LYS474 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| C | LYS114 | |
| A | LYS114 | |
| B | LYS114 | |
| D | LYS114 | |
| E | LYS114 | |
| F | LYS114 | |
| G | LYS114 | |
| H | LYS114 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 24 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| D | LYS265 | |
| D | LYS269 | |
| E | LYS265 | |
| E | LYS269 | |
| F | LYS265 | |
| F | LYS269 | |
| C | LYS265 | |
| G | LYS265 | |
| G | LYS269 | |
| H | LYS265 | |
| H | LYS269 | |
| C | LYS269 | |
| A | LYS265 | |
| A | LYS269 | |
| B | LYS265 | |
| B | LYS269 |
| site_id | SWS_FT_FI29 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate => ECO:0007744|PubMed:25114211 |
| Chain | Residue | Details |
| C | LYS165 | |
| A | LYS165 | |
| B | LYS165 | |
| D | LYS165 | |
| E | LYS165 | |
| F | LYS165 | |
| G | LYS165 | |
| H | LYS165 |
