3SP8
Crystal structure of NK2 in complex with fractionated Heparin DP10
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Hepatocyte growth factor alpha chain | polymer | 264 | 30910.1 | 2 | UniProt (P14210) Pfam (PF00024) Pfam (PF00051) | Homo sapiens (human) | Hepatopoeitin-A, Scatter factor, SF |
| 2 | C, F, G, O (A, B) | (4R)-2-METHYLPENTANE-2,4-DIOL | non-polymer | 118.2 | 4 | Chemie (MRD) | |||
| 3 | D, E, P, Q (A, B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 4 | Chemie (MES) | |||
| 4 | H (A) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 1 | Chemie (MPD) | |||
| 5 | I, J, K, L, M... (A, B) | SULFATE ION | non-polymer | 96.1 | 10 | Chemie (SO4) | |||
| 6 | V, W (A, B) | water | water | 18.0 | 359 | Chemie (HOH) |
Sequence modifications
A, B: 28 - 288 (UniProt: P14210)
| PDB | External Database | Details |
|---|---|---|
| Gly 26 | - | expression tag |
| Ser 27 | - | expression tag |
| Asp 146 | Gly 146 | engineered mutation |
| Ser 214 | Cys 214 | engineered mutation |
| Lys 284 | Ala 284 | conflict |
| Lys 289 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 61820.2 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 2332.4 | |
| All* | Total formula weight | 64152.7 |
