3SN5
Crystal structure of human CYP7A1 in complex with cholest-4-en-3-one
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cholesterol 7-alpha-monooxygenase | polymer | 491 | 56481.8 | 2 | UniProt (P22680) Pfam (PF00067) | Homo sapiens (human) | CYP7A1, CYPVII, Cholesterol 7-alpha-hydroxylase, Cytochrome P450 7A1 |
| 2 | C, I (A, B) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 3 | D, J (A, B) | (8ALPHA,9BETA)-CHOLEST-4-EN-3-ONE | non-polymer | 384.6 | 2 | Chemie (K2B) | |||
| 4 | E, F, G, H, K... (A, B) | UNKNOWN ATOM OR ION | non-polymer | 8 | Chemie (UNX) | ||||
| 5 | O, P (A, B) | water | water | 18.0 | 36 | Chemie (HOH) |
Sequence modifications
A, B: 25 - 503 (UniProt: P22680)
| PDB | External Database | Details |
|---|---|---|
| Met 18 | - | expression tag |
| Ala 19 | - | expression tag |
| Lys 20 | - | expression tag |
| Lys 21 | - | expression tag |
| Thr 22 | - | expression tag |
| Ser 23 | - | expression tag |
| Ser 24 | - | expression tag |
| Leu 104 | Thr 104 | engineered mutation |
| His 504 | - | expression tag |
| His 505 | - | expression tag |
| His 506 | - | expression tag |
| His 507 | - | expression tag |
| His 508 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 112963.7 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2002.3 | |
| All* | Total formula weight | 114965.9 |
