3SLS
Crystal Structure of human MEK-1 kinase in complex with UCB1353770 and AMPPNP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dual specificity mitogen-activated protein kinase kinase 1 | polymer | 304 | 33893.2 | 2 | UniProt (Q02750) Pfam (PF00069) | Homo sapiens (human) | MAP kinase kinase 1, MAPKK 1, MKK1, ERK activator kinase 1, MAPK/ERK kinase 1, MEK 1 |
| 2 | C, F (A, B) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 2 | Chemie (ANP) | |||
| 3 | D, G (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E, H (A, B) | 2-[(2-fluoro-4-iodophenyl)amino]-5,5-dimethyl-8-oxo-N-[(3R)-piperidin-3-yl]-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepine-3-carboxamide | non-polymer | 556.4 | 2 | Chemie (77D) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 360 | Chemie (HOH) |
Sequence modifications
A, B: 45 - 345 (UniProt: Q02750)
| PDB | External Database | Details |
|---|---|---|
| Met 42 | - | expression tag |
| Thr 43 | - | expression tag |
| Leu 44 | - | expression tag |
| Gly 264 | - | insertion |
| Ser 265 | - | insertion |
| Gly 266 | - | insertion |
| Ser 267 | - | insertion |
| Gly 268 | - | insertion |
| Ser 269 | - | insertion |
| - | Pro 264 | deletion |
| - | Pro 265 | deletion |
| - | Pro 266 | deletion |
| - | Asp 267 | deletion |
| - | Ala 268 | deletion |
| - | Lys 269 | deletion |
| - | Glu 270 | deletion |
| - | Leu 271 | deletion |
| - | Glu 272 | deletion |
| - | Leu 273 | deletion |
| - | Met 274 | deletion |
| - | Phe 275 | deletion |
| - | Gly 276 | deletion |
| - | Cys 277 | deletion |
| - | Gln 278 | deletion |
| - | Val 279 | deletion |
| - | Glu 280 | deletion |
| - | Gly 281 | deletion |
| - | Asp 282 | deletion |
| - | Ala 283 | deletion |
| - | Ala 284 | deletion |
| - | Glu 285 | deletion |
| - | Thr 286 | deletion |
| - | Pro 287 | deletion |
| - | Pro 288 | deletion |
| - | Arg 289 | deletion |
| - | Pro 290 | deletion |
| - | Arg 291 | deletion |
| - | Thr 292 | deletion |
| - | Pro 293 | deletion |
| - | Gly 294 | deletion |
| - | Arg 295 | deletion |
| - | Pro 296 | deletion |
| - | Leu 297 | deletion |
| - | Ser 298 | deletion |
| - | Ser 299 | deletion |
| - | Tyr 300 | deletion |
| - | Gly 301 | deletion |
| - | Met 302 | deletion |
| - | Asp 303 | deletion |
| - | Ser 304 | deletion |
| - | Arg 305 | deletion |
| - | Pro 306 | deletion |
| - | Pro 307 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67786.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2173.9 | |
| All* | Total formula weight | 69960.3 |
