3SHR

Crystal Structure of cGMP-dependent Protein Kinase Reveals Novel Site of Interchain Communication

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	cGMP-dependent protein kinase 1	polymer	299	33680.5	2	UniProt (P00516) Pfam (PF00027) In PDB	Bos taurus (bovine cow domestic cattle domestic cow)	cGK 1, cGK1, cGMP-dependent protein kinase I, cGKI
2	A, B	ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE	non-polymer		329.2	2	Chemie (CMP)
3	A	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)

Sequence modifications

A, B: 78 - 355 (UniProt: P00516)

PDB	External Database	Details
Met 57	-	expression tag
Arg 58	-	expression tag
Gly 59	-	expression tag
Ser 60	-	expression tag
His 61	-	expression tag
His 62	-	expression tag
His 63	-	expression tag
His 64	-	expression tag
His 65	-	expression tag
His 66	-	expression tag
Gly 67	-	expression tag
Met 68	-	expression tag
Ala 69	-	expression tag
Ser 70	-	expression tag
Ile 71	-	expression tag
Glu 72	-	expression tag
Gly 73	-	expression tag
Arg 74	-	expression tag
Gly 75	-	expression tag
Ser 76	-	expression tag
Met 77	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	67360.9
Non-Polymers*	Number of molecules	4
	Total formula weight	850.5
All*	Total formula weight	68211.5

*Water molecules are not included.