3SE6

Crystal structure of the human Endoplasmic Reticulum Aminopeptidase 2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Endoplasmic reticulum aminopeptidase 2	polymer	967	111515.4	2	UniProt (Q6P179) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838) In PDB	Homo sapiens (human)	Leukocyte-derived arginine aminopeptidase, L-RAP
2	C, D	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
3	E	alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81874LD)
4	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	A, B	LYSINE	non-polymer		147.2	2	Chemie (LYS)
6	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)
7	A, B	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	2	Chemie (MES)
8		water	water		18.0	126	Chemie (HOH)

Sequence modifications

A, B: 1 - 960 (UniProt: Q6P179)

PDB	External Database	Details
Val 2	Phe 2	engineered mutation
Asn 392	Lys 392	SEE REMARK 999
Arg 961	-	expression tag
His 962	-	expression tag
His 963	-	expression tag
His 964	-	expression tag
His 965	-	expression tag
His 966	-	expression tag
His 967	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	223030.8
Branched	Number of molecules	3
	Total formula weight	1597.5
Non-Polymers*	Number of molecules	9
	Total formula weight	1479.3
All*	Total formula weight	226107.5

*Water molecules are not included.