3SE3
human IFNa2-IFNAR ternary complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Interferon alpha/beta receptor 1 | polymer | 414 | 47630.0 | 1 | UniProt (P17181) Pfam (PF01108) Pfam (PF09294) | Homo sapiens (human) | IFN-R-1, IFN-alpha/beta receptor 1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, CRF2-1, Type I interferon receptor 1 |
| 2 | B (B) | Interferon alpha 2b | polymer | 166 | 19392.3 | 1 | UniProt (Q86UP4) Pfam (PF00143) UniProt (by SIFTS) (P01563) | Homo sapiens (human) | |
| 3 | C (C) | Interferon alpha/beta receptor 2 | polymer | 199 | 22894.1 | 1 | UniProt (P48551) Pfam (PF01108) Pfam (PF09294) | Homo sapiens (human) | IFN-R-2, IFN-alpha binding protein, IFN-alpha/beta receptor 2, Interferon alpha binding protein, Type I interferon receptor 2 |
| 4 | D (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) |
Sequence modifications
A: 1 - 409 (UniProt: P17181)
B: 0 - 165 (UniProt: Q86UP4)
| PDB | External Database | Details |
|---|---|---|
| Ala -4 | - | cloning artifact |
| Asp -3 | - | cloning artifact |
| Leu -2 | - | cloning artifact |
| Gly -1 | - | cloning artifact |
| Ser 0 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Tyr 57 | His 58 | engineered mutation |
| Asn 58 | Glu 59 | engineered mutation |
| Ser 61 | Gln 62 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 89916.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 90137.5 |
