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3SE3

human IFNa2-IFNAR ternary complex

Functional Information from GO Data
ChainGOidnamespacecontents
B0002250biological_processadaptive immune response
B0002286biological_processT cell activation involved in immune response
B0002323biological_processnatural killer cell activation involved in immune response
B0005125molecular_functioncytokine activity
B0005126molecular_functioncytokine receptor binding
B0005132molecular_functiontype I interferon receptor binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006915biological_processapoptotic process
B0006952biological_processdefense response
B0006954biological_processinflammatory response
B0006959biological_processhumoral immune response
B0007166biological_processcell surface receptor signaling pathway
B0007267biological_processcell-cell signaling
B0010629biological_processnegative regulation of gene expression
B0019221biological_processcytokine-mediated signaling pathway
B0030183biological_processB cell differentiation
B0032696biological_processnegative regulation of interleukin-13 production
B0032714biological_processnegative regulation of interleukin-5 production
B0033141biological_processpositive regulation of peptidyl-serine phosphorylation of STAT protein
B0042100biological_processB cell proliferation
B0043330biological_processresponse to exogenous dsRNA
B0045581biological_processnegative regulation of T cell differentiation
B0045892biological_processnegative regulation of DNA-templated transcription
B0046597biological_processnegative regulation of viral entry into host cell
B0051607biological_processdefense response to virus
B0060337biological_processtype I interferon-mediated signaling pathway
B0062023cellular_componentcollagen-containing extracellular matrix
B0097696biological_processcell surface receptor signaling pathway via STAT
B0098586biological_processcellular response to virus
B2000552biological_processnegative regulation of T-helper 2 cell cytokine production
Functional Information from PROSITE/UniProt
site_idPS00252
Number of Residues19
DetailsINTERFERON_A_B_D Interferon alpha, beta and delta family signature. YFqRItlYLkekkyspCAW
ChainResidueDetails
BTYR122-TRP140

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsCARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:2049076
ChainResidueDetails
BTHR106
CASN89
CASN161

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:8181059
ChainResidueDetails
CASN60
CASN165
AASN61
AASN227
AASN287
AASN349
AASN389
AASN406

site_idSWS_FT_FI3
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973
ChainResidueDetails
AASN31
AASN83
AASN286

site_idSWS_FT_FI4
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21854986, ECO:0007744|PDB:3S98
ChainResidueDetails
AASN145

222926

PDB entries from 2024-07-24

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