3SAI
Bacuills anthracis Dihydrofolate Reductase bound to propargyl-linked TMP analog, UCP1015
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Dihydrofolate reductase | polymer | 165 | 19607.3 | 2 | UniProt (Q81R22) Pfam (PF00186) In PDB | Bacillus anthracis (anthrax anthrax bacterium) | |
2 | A, B | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
3 | A, B | 6-ethyl-5-{3-[3-methoxy-5-(pyridin-4-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine | non-polymer | 359.4 | 2 | Chemie (9DR) | |||
4 | A, B | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) | |||
5 | A | NICKEL (II) ION | non-polymer | 58.7 | 1 | Chemie (NI) | |||
6 | water | water | 18.0 | 229 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 162 (UniProt: Q81R22)
PDB | External Database | Details |
---|---|---|
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
Arg 2 | Ile 2 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 39214.7 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 2688.8 | |
All* | Total formula weight | 41903.5 |