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3SAI

Bacuills anthracis Dihydrofolate Reductase bound to propargyl-linked TMP analog, UCP1015

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0004146molecular_functiondihydrofolate reductase activity
A0005829cellular_componentcytosol
A0006730biological_processone-carbon metabolic process
A0016491molecular_functionoxidoreductase activity
A0046452biological_processdihydrofolate metabolic process
A0046654biological_processtetrahydrofolate biosynthetic process
A0046655biological_processfolic acid metabolic process
A0046872molecular_functionmetal ion binding
A0050661molecular_functionNADP binding
B0000166molecular_functionnucleotide binding
B0004146molecular_functiondihydrofolate reductase activity
B0005829cellular_componentcytosol
B0006730biological_processone-carbon metabolic process
B0016491molecular_functionoxidoreductase activity
B0046452biological_processdihydrofolate metabolic process
B0046654biological_processtetrahydrofolate biosynthetic process
B0046655biological_processfolic acid metabolic process
B0046872molecular_functionmetal ion binding
B0050661molecular_functionNADP binding
Functional Information from PDB Data
site_idAC1
Number of Residues32
DetailsBINDING SITE FOR RESIDUE NAP A 207
ChainResidue
AVAL7
ALYS46
ALYS46
AASN47
AVAL63
ATHR64
AARG65
AHIS78
APHE96
AGLY97
AGLY98
AALA8
AALA99
AGLN100
AILE101
ATYR102
ALEU104
A9DR163
APEG167
AHOH179
AHOH192
AHOH220
AILE15
AHOH234
AHOH244
AHOH259
AGLY16
AASN19
AASN20
ALEU21
AGLY44
AARG45

site_idAC2
Number of Residues14
DetailsBINDING SITE FOR RESIDUE 9DR A 163
ChainResidue
AMET6
AVAL7
AALA8
AASN20
AGLU28
ALEU29
AVAL32
AASN47
AILE51
AARG53
ALEU55
APHE96
ATYR102
ANAP207

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PEG A 164
ChainResidue
ASER27
ATYR31
ALYS34
AGLU141

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PEG A 165
ChainResidue
AASN66
AGLY68
AHIS70

site_idAC5
Number of Residues1
DetailsBINDING SITE FOR RESIDUE NI A 166
ChainResidue
ATHR145

site_idAC6
Number of Residues2
DetailsBINDING SITE FOR RESIDUE PEG A 167
ChainResidue
AARG65
ANAP207

site_idAC7
Number of Residues34
DetailsBINDING SITE FOR RESIDUE NAP B 207
ChainResidue
BVAL7
BALA8
BILE15
BGLY16
BASN19
BASN20
BLEU21
BGLY44
BARG45
BLYS46
BLYS46
BASN47
BVAL63
BTHR64
BARG65
BHIS78
BPHE96
BGLY97
BGLY98
BALA99
BGLN100
BILE101
BTYR102
BLEU104
BTHR125
B9DR163
BHOH175
BHOH179
BHOH180
BHOH204
BHOH213
BHOH218
BHOH224
BHOH244

site_idAC8
Number of Residues12
DetailsBINDING SITE FOR RESIDUE 9DR B 163
ChainResidue
BPHE96
BTYR102
BNAP207
BMET6
BVAL7
BALA8
BASN20
BGLU28
BLEU29
BVAL32
BASN47
BALA50

site_idAC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PEG B 164
ChainResidue
BASP146
BPRO150
BHOH193

Functional Information from PROSITE/UniProt
site_idPS00075
Number of Residues23
DetailsDHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGkdnnLPWrlps.ElqyVkktT
ChainResidueDetails
AVAL14-THR36

222036

PDB entries from 2024-07-03

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