Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0050661 | molecular_function | NADP binding |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004146 | molecular_function | dihydrofolate reductase activity |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
B | 0046872 | molecular_function | metal ion binding |
B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 32 |
Details | BINDING SITE FOR RESIDUE NAP A 207 |
Chain | Residue |
A | VAL7 |
A | LYS46 |
A | LYS46 |
A | ASN47 |
A | VAL63 |
A | THR64 |
A | ARG65 |
A | HIS78 |
A | PHE96 |
A | GLY97 |
A | GLY98 |
A | ALA8 |
A | ALA99 |
A | GLN100 |
A | ILE101 |
A | TYR102 |
A | LEU104 |
A | 9DR163 |
A | PEG167 |
A | HOH179 |
A | HOH192 |
A | HOH220 |
A | ILE15 |
A | HOH234 |
A | HOH244 |
A | HOH259 |
A | GLY16 |
A | ASN19 |
A | ASN20 |
A | LEU21 |
A | GLY44 |
A | ARG45 |
site_id | AC2 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE 9DR A 163 |
Chain | Residue |
A | MET6 |
A | VAL7 |
A | ALA8 |
A | ASN20 |
A | GLU28 |
A | LEU29 |
A | VAL32 |
A | ASN47 |
A | ILE51 |
A | ARG53 |
A | LEU55 |
A | PHE96 |
A | TYR102 |
A | NAP207 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PEG A 164 |
Chain | Residue |
A | SER27 |
A | TYR31 |
A | LYS34 |
A | GLU141 |
site_id | AC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PEG A 165 |
Chain | Residue |
A | ASN66 |
A | GLY68 |
A | HIS70 |
site_id | AC5 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE NI A 166 |
site_id | AC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PEG A 167 |
Chain | Residue |
A | ARG65 |
A | NAP207 |
site_id | AC7 |
Number of Residues | 34 |
Details | BINDING SITE FOR RESIDUE NAP B 207 |
Chain | Residue |
B | VAL7 |
B | ALA8 |
B | ILE15 |
B | GLY16 |
B | ASN19 |
B | ASN20 |
B | LEU21 |
B | GLY44 |
B | ARG45 |
B | LYS46 |
B | LYS46 |
B | ASN47 |
B | VAL63 |
B | THR64 |
B | ARG65 |
B | HIS78 |
B | PHE96 |
B | GLY97 |
B | GLY98 |
B | ALA99 |
B | GLN100 |
B | ILE101 |
B | TYR102 |
B | LEU104 |
B | THR125 |
B | 9DR163 |
B | HOH175 |
B | HOH179 |
B | HOH180 |
B | HOH204 |
B | HOH213 |
B | HOH218 |
B | HOH224 |
B | HOH244 |
site_id | AC8 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE 9DR B 163 |
Chain | Residue |
B | PHE96 |
B | TYR102 |
B | NAP207 |
B | MET6 |
B | VAL7 |
B | ALA8 |
B | ASN20 |
B | GLU28 |
B | LEU29 |
B | VAL32 |
B | ASN47 |
B | ALA50 |
site_id | AC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PEG B 164 |
Chain | Residue |
B | ASP146 |
B | PRO150 |
B | HOH193 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGkdnnLPWrlps.ElqyVkktT |
Chain | Residue | Details |
A | VAL14-THR36 | |