3S9L

Complex between transferrin receptor 1 and transferrin with iron in the N-Lobe, cryocooled 2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Transferrin receptor protein 1	polymer	654	73533.2	2	UniProt (P02786) Pfam (PF02225) Pfam (PF04389) Pfam (PF04253) In PDB	Homo sapiens (human)	TR, TfR, TfR1, Trfr, T9, p90, Transferrin receptor protein 1, serum form, sTfR
2	C, D	Serotransferrin	polymer	693	76980.4	2	UniProt (P02787) Pfam (PF00405) In PDB	Homo sapiens (human)	Transferrin, Beta-1 metal-binding globulin, Siderophilin
3	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
4	A, B	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
5	C, D	FE (III) ION	non-polymer		55.8	2	Chemie (FE)
6	C, D	CARBONATE ION	non-polymer		60.0	2	Chemie (CO3)

Sequence modifications

A, B: 120 - 760 (UniProt: P02786)

PDB	External Database	Details
Val 107	-	expression tag
Pro 108	-	expression tag
Asp 109	-	expression tag
Lys 110	-	expression tag
His 111	-	expression tag
His 112	-	expression tag
His 113	-	expression tag
His 114	-	expression tag
His 115	-	expression tag
His 116	-	expression tag
Ile 117	-	expression tag
Glu 118	-	expression tag
Gly 119	-	expression tag
Ser 142	Gly 142	SEE REMARK 999

C, D: 1 - 679 (UniProt: P02787)

PDB	External Database	Details
Val -13	-	expression tag
Pro -12	-	expression tag
Asp -11	-	expression tag
Lys -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Ile -3	-	expression tag
Glu -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag
Asp 413	Asn 432	engineered mutation
Phe 426	Tyr 445	engineered mutation
Val 429	Ile 448	SEE REMARK 999
Phe 517	Tyr 536	engineered mutation
Asp 611	Asn 630	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	301027.0
Non-Polymers*	Number of molecules	8
	Total formula weight	754.3
All*	Total formula weight	301781.3

*Water molecules are not included.