3S7K
Structure of thrombin mutant Y225P in the E form
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Prothrombin | polymer | 35 | 3995.4 | 2 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | Coagulation factor II, Activation peptide fragment 1, Activation peptide fragment 2, Thrombin light chain, Thrombin heavy chain |
| 2 | B, D (B, D) | Prothrombin | polymer | 259 | 29714.2 | 2 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | Coagulation factor II, Activation peptide fragment 1, Activation peptide fragment 2, Thrombin light chain, Thrombin heavy chain |
| 3 | E, G (A, C) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 4 | F, H (B, D) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 2 | Chemie (TRS) | |||
| 5 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 384 | Chemie (HOH) |
Sequence modifications
B, D: 16 - 247 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Pro 225 | Tyr 600 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 67419.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 322.5 | |
| All* | Total formula weight | 67741.7 |
