3S43
HIV-1 protease triple mutants V32I, I47V, V82I with antiviral drug amprenavir
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Protease | polymer | 99 | 10755.7 | 1 | UniProt (Q7SSE3) Pfam (PF00077) In PDB | Human immunodeficiency virus 1 | |
2 | B | Protease | polymer | 99 | 10754.7 | 1 | UniProt (Q7SSE3) Pfam (PF00077) UniProt (by SIFTS) (Q7SSI0) In PDB | Human immunodeficiency virus 1 | |
3 | A | {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER | non-polymer | 505.6 | 1 | Chemie (478) | |||
4 | A, B | IODIDE ION | non-polymer | 126.9 | 17 | Chemie (IOD) | |||
5 | A, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
6 | water | water | 18.0 | 126 | Chemie (HOH) |
Sequence modifications
A: 1 - 99 (UniProt: Q7SSE3)
B: 101 - 199 (UniProt: Q7SSE3)
PDB | External Database | Details |
---|---|---|
Lys 7 | Gln 7 | engineered mutation |
Ile 32 | Val 32 | engineered mutation |
Ile 33 | Leu 33 | engineered mutation |
Val 47 | Ile 47 | engineered mutation |
Ile 63 | Leu 63 | engineered mutation |
Ala 67 | Cys 67 | engineered mutation |
His 69 | Tyr 69 | engineered mutation |
Ala 95 | Ser 95 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Lys 107 | Gln 7 | engineered mutation |
Ile 132 | Val 32 | engineered mutation |
Ile 133 | Leu 33 | engineered mutation |
Val 147 | Ile 47 | engineered mutation |
Ile 163 | Leu 63 | engineered mutation |
Ala 167 | Cys 67 | engineered mutation |
His 169 | Tyr 69 | engineered mutation |
Ala 195 | Ser 95 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 21510.4 | |
Non-Polymers* | Number of molecules | 20 |
Total formula weight | 2847.2 | |
All* | Total formula weight | 24357.6 |