3RU0
Cocrystal structure of human SMYD3 with inhibitor Sinefungin bound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | SET and MYND domain-containing protein 3 | polymer | 438 | 50349.4 | 2 | UniProt (Q9H7B4) Pfam (PF00856) Pfam (PF01753) | Homo sapiens (human) | Zinc finger MYND domain-containing protein 1 |
| 2 | C, G (A, B) | SINEFUNGIN | non-polymer | 381.4 | 2 | Chemie (SFG) | |||
| 3 | D, E, F, H, I... (A, B) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 4 | K, L (A, B) | water | water | 18.0 | 482 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 428 (UniProt: Q9H7B4)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Leu 1 | - | expression tag |
| Asn 13 | Lys 13 | conflict |
| Glu 429 | - | expression tag |
| Gly 430 | - | expression tag |
| His 431 | - | expression tag |
| His 432 | - | expression tag |
| His 433 | - | expression tag |
| His 434 | - | expression tag |
| His 435 | - | expression tag |
| His 436 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 100698.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1155.2 | |
| All* | Total formula weight | 101854.0 |
