3RTR
A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G | Cullin-1 | polymer | 368 | 42694.0 | 4 | UniProt (Q13616) Pfam (PF00888) Pfam (PF10557) In PDB | Homo sapiens (human) | CUL-1 |
| 2 | B, D, F, H | E3 ubiquitin-protein ligase RBX1 | polymer | 106 | 12089.7 | 4 | UniProt (P62877) Pfam (PF12678) In PDB | Homo sapiens (human) | Protein ZYP, RING finger protein 75, RING-box protein 1, Rbx1, Regulator of cullins 1 |
| 3 | B, D, F, H | ZINC ION | non-polymer | 65.4 | 12 | Chemie (ZN) |
Sequence modifications
A, C, E, G: 411 - 776 (UniProt: Q13616)
B, D, F, H: 5 - 108 (UniProt: P62877)
| PDB | External Database | Details |
|---|---|---|
| Gly 409 | - | expression tag |
| Ser 410 | - | expression tag |
| Glu 421 | Leu 421 | engineered mutation |
| Glu 451 | Val 451 | engineered mutation |
| Lys 452 | Val 452 | engineered mutation |
| Lys 455 | Tyr 455 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 3 | - | expression tag |
| Ser 4 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 219134.8 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 784.9 | |
| All* | Total formula weight | 219919.8 |
