3RI1
Crystal structure of the catalytic domain of FGFR2 kinase in complex with ARQ 069
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Fibroblast growth factor receptor 2 | polymer | 313 | 35765.2 | 2 | UniProt (P21802) Pfam (PF07714) | Homo sapiens (human) | FGFR-2, K-sam, Keratinocyte growth factor receptor |
| 2 | C, I (A, B) | (6S)-6-phenyl-5,6-dihydrobenzo[h]quinazolin-2-amine | non-polymer | 273.3 | 2 | Chemie (3RH) | |||
| 3 | D, E, F, G, H... (A, B) | SULFATE ION | non-polymer | 96.1 | 9 | Chemie (SO4) | |||
| 4 | N, O (A, B) | water | water | 18.0 | 412 | Chemie (HOH) |
Sequence modifications
A, B: 458 - 768 (UniProt: P21802)
| PDB | External Database | Details |
|---|---|---|
| Gly 456 | - | expression tag |
| Ser 457 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71530.4 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1411.2 | |
| All* | Total formula weight | 72941.6 |
