3RI1
Crystal structure of the catalytic domain of FGFR2 kinase in complex with ARQ 069
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004713 | molecular_function | protein tyrosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 3RH A 2 |
| Chain | Residue |
| A | SO46 |
| A | LEU633 |
| A | HOH229 |
| A | HOH324 |
| A | VAL495 |
| A | ALA515 |
| A | GLU534 |
| A | VAL564 |
| A | GLU565 |
| A | ALA567 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 3 |
| Chain | Residue |
| A | HOH308 |
| A | THR635 |
| A | ASN637 |
| A | VAL639 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 7 |
| Chain | Residue |
| A | HOH194 |
| A | HOH215 |
| A | ARG625 |
| A | ARG649 |
| A | THR660 |
| A | THR661 |
| A | ASN662 |
| A | GLY663 |
| A | ARG664 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 4 |
| Chain | Residue |
| A | HOH127 |
| A | THR681 |
| A | HIS682 |
| A | GLN683 |
| B | ARG612 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 11 |
| Chain | Residue |
| A | HOH58 |
| A | ARG580 |
| A | GLY701 |
| A | SER702 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 6 |
| Chain | Residue |
| A | 3RH2 |
| A | HOH145 |
| A | HOH172 |
| A | HOH286 |
| A | HOH309 |
| A | GLU489 |
| A | GLY490 |
| A | CYS491 |
| A | PHE492 |
| A | GLY493 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 3RH B 1 |
| Chain | Residue |
| B | HOH326 |
| B | HOH419 |
| B | VAL495 |
| B | ALA515 |
| B | LYS517 |
| B | VAL564 |
| B | GLU565 |
| B | ALA567 |
| B | LEU633 |
| B | SO4769 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 9 |
| Chain | Residue |
| A | HOH76 |
| B | HOH226 |
| B | VAL709 |
| B | GLU710 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 8 |
| Chain | Residue |
| B | HOH213 |
| B | HOH330 |
| B | ARG625 |
| B | THR660 |
| B | ASN662 |
| B | GLY663 |
| B | ARG664 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 769 |
| Chain | Residue |
| B | 3RH1 |
| B | HOH416 |
| B | GLU489 |
| B | GLY490 |
| B | CYS491 |
| B | PHE492 |
| B | GLY493 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 5 |
| Chain | Residue |
| B | HOH137 |
| B | HOH205 |
| B | ARG577 |
| B | ARG580 |
| B | GLY700 |
| B | GLY701 |
| B | SER702 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 31 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGCFGQVVmAeavgidkdkpkeavt...VAVK |
| Chain | Residue | Details |
| A | LEU487-LYS517 |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV |
| Chain | Residue | Details |
| A | CYS622-VAL634 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19060208","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19060208","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"17803937","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19060208","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19410646","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
