3RBU
N-terminally AviTEV-tagged Human Glutamate Carboxypeptidase II in complex with 2-PMPA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glutamate carboxypeptidase 2 | polymer | 739 | 83200.6 | 1 | UniProt (Q04609) Pfam (PF02225) Pfam (PF04389) Pfam (PF04253) | Homo sapiens (human) | Cell growth-inhibiting gene 27 protein, Folate hydrolase 1, Folylpoly-gamma-glutamate carboxypeptidase, FGCP, GCPII, Membrane glutamate carboxypeptidase, mGCP, N-acetylated-alpha-linked acidic dipeptidase I, NAALADase I, Prostate-specific membrane antigen, PSM, PSMA, Pteroylpoly-gamma-glutamate carboxypeptidase |
| 2 | B, C (B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 3 | D (D) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 4 | E (E) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
| 5 | F, G, H (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 6 | I, J (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 7 | K (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 8 | L (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 9 | M (A) | (2S)-2-(PHOSPHONOMETHYL)PENTANEDIOIC ACID | non-polymer | 226.1 | 1 | Chemie (G88) | |||
| 10 | N (A) | water | water | 18.0 | 696 | Chemie (HOH) |
Sequence modifications
A: 44 - 750 (UniProt: Q04609)
| PDB | External Database | Details |
|---|---|---|
| Arg 12 | - | expression tag |
| Ser 13 | - | expression tag |
| Gly 14 | - | expression tag |
| Leu 15 | - | expression tag |
| Asn 16 | - | expression tag |
| Asp 17 | - | expression tag |
| Ile 18 | - | expression tag |
| Phe 19 | - | expression tag |
| Glu 20 | - | expression tag |
| Ala 21 | - | expression tag |
| Gln 22 | - | expression tag |
| Lys 23 | - | expression tag |
| Ile 24 | - | expression tag |
| Glu 25 | - | expression tag |
| Trp 26 | - | expression tag |
| His 27 | - | expression tag |
| Glu 28 | - | expression tag |
| Gly 29 | - | expression tag |
| Ser 30 | - | expression tag |
| Gly 31 | - | expression tag |
| Ser 32 | - | expression tag |
| Gly 33 | - | expression tag |
| Ser 34 | - | expression tag |
| Glu 35 | - | expression tag |
| Asn 36 | - | expression tag |
| Leu 37 | - | expression tag |
| Tyr 38 | - | expression tag |
| Phe 39 | - | expression tag |
| Gln 40 | - | expression tag |
| Gly 41 | - | expression tag |
| Arg 42 | - | expression tag |
| Ser 43 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 83200.6 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 2184.0 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1096.1 | |
| All* | Total formula weight | 86480.7 |
