3R45

Structure of a CENP-A-Histone H4 Heterodimer in complex with chaperone HJURP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Histone H3-like centromeric protein A	polymer	156	17843.5	1	UniProt (P49450) Pfam (PF00125)	Homo sapiens (human)	Centromere autoantigen A, Centromere protein A, CENP-A
2	B (B)	Histone H4	polymer	103	11394.4	1	UniProt (P62805) Pfam (PF15511)	Homo sapiens (human)
3	C (C)	Holliday junction recognition protein	polymer	81	9637.0	1	UniProt (Q8NCD3) Pfam (PF10384)	Homo sapiens (human)	HJURP, 14-3-3-associated AKT substrate, Fetal liver-expressing gene 1 protein, Up-regulated in lung cancer 9
4	D, E, F, G, I... (A, B, C)	SULFATE ION	non-polymer		96.1	13	Chemie (SO4)
5	H, M, S (A, B, C)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
6	T, U, V (A, B, C)	water	water		18.0	34	Chemie (HOH)

Sequence modifications

A: 1 - 140 (UniProt: P49450)

PDB	External Database	Details
Met -15	-	expression tag
Gly -14	-	expression tag
Ser -13	-	expression tag
Ser -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
Ser -5	-	expression tag
Gln -4	-	expression tag
Asp -3	-	expression tag
Pro -2	-	expression tag
Asn -1	-	expression tag
Ser 0	-	expression tag

C: 1 - 80 (UniProt: Q8NCD3)

PDB	External Database	Details
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	38874.9
Non-Polymers*	Number of molecules	16
	Total formula weight	1525.1
All*	Total formula weight	40400.0

*Water molecules are not included.