3QM4

Human Cytochrome P450 (CYP) 2D6 - Prinomastat Complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Cytochrome P450 2D6	polymer	479	53730.6	2	UniProt (P10635) Pfam (PF00067) In PDB	Homo sapiens (human)	CYPIID6, Cytochrome P450-DB1, Debrisoquine 4-hydroxylase
2	A, B	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	2	Chemie (HEM)
3	A, B	Prinomastat	non-polymer		423.5	2	Chemie (PN0)
4	B	NICKEL (II) ION	non-polymer		58.7	1	Chemie (NI)
5		water	water		18.0	7	Chemie (HOH)

Sequence modifications

A, B: 34 - 497 (UniProt: P10635)

PDB	External Database	Details
Met 23	-	expression tag
Ala 24	-	expression tag
Lys 25	-	expression tag
Lys 26	-	expression tag
Thr 27	-	expression tag
Ser 28	-	expression tag
Ser 29	-	expression tag
Lys 30	-	expression tag
Gly 31	-	expression tag
Lys 32	-	expression tag
Leu 33	-	expression tag
His 498	-	expression tag
His 499	-	expression tag
His 500	-	expression tag
His 501	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	107461.1
Non-Polymers*	Number of molecules	5
	Total formula weight	2138.7
All*	Total formula weight	109599.8

*Water molecules are not included.