3QHW
Structure of a pCDK2/CyclinA transition-state mimic
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | Cell division protein kinase 2 | polymer | 298 | 33981.3 | 2 | UniProt (P24941) Pfam (PF00069) In PDB | Homo sapiens (human) | p33 protein kinase |
| 2 | B, D | Cyclin-A2 | polymer | 261 | 29836.4 | 2 | UniProt (P51943) Pfam (PF00134) Pfam (PF02984) In PDB | Mus musculus (mouse) | Cyclin-A |
| 3 | J, K, L, M | CDK2 substrate peptide: PKTPKKAKKL | polymer | 10 | 1143.5 | 4 | |||
| 4 | A, C | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) | |||
| 5 | A, C | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 6 | A, C | TRIFLUOROMAGNESATE | non-polymer | 81.3 | 2 | Chemie (MGF) | |||
| 7 | A, C | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 8 | B, D | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL | non-polymer | 154.3 | 2 | Chemie (DTU) | |||
| 9 | water | water | 18.0 | 793 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 296 (UniProt: P24941)
B, D: 173 - 432 (UniProt: P51943)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| His 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 172 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 132209.3 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1493.6 | |
| All* | Total formula weight | 133702.9 |
