3QGI
Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase genotype 1a complex with N-[(2S)-butan-2-yl]-6-[(3R)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | RNA-directed RNA polymerase | polymer | 571 | 63018.3 | 1 | UniProt (B1PBP5) Pfam (PF00998) UniProt (by SIFTS) (P26664) | Hepatitis C virus subtype 1a | |
| 2 | B (A) | N-[(2S)-butan-2-yl]-6-[(3R)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide | non-polymer | 704.6 | 1 | Chemie (33F) | |||
| 3 | C, D, E, F, G... (A) | GLYCEROL | non-polymer | 92.1 | 14 | Chemie (GOL) | |||
| 4 | Q (A) | water | water | 18.0 | 541 | Chemie (HOH) |
Sequence modifications
A: 1 - 568 (UniProt: B1PBP5)
| PDB | External Database | Details |
|---|---|---|
| Ala 0 | - | expression tag |
| Pro 569 | - | expression tag |
| Arg 570 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 63018.3 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 1994.0 | |
| All* | Total formula weight | 65012.3 |
