3QAE

3-hydroxy-3-methylglutaryl-coenzyme A reductase of Streptococcus pneumoniae

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	3-hydroxy-3-methylglutaryl-coenzyme a reductase	polymer	458	49845.6	1	UniProt (Q8DNS5) Pfam (PF00368) In PDB	Streptococcus pneumoniae	HMG-CoA reductase
2	A	CITRIC ACID	non-polymer		192.1	1	Chemie (CIT)
3	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	A	SODIUM ION	non-polymer		23.0	27	Chemie (NA)
5		water	water		18.0	107	Chemie (HOH)

Sequence modifications

A: 1 - 424 (UniProt: Q8DNS5)

PDB	External Database	Details
Met -33	-	expression tag
Gly -32	-	expression tag
Ser -31	-	expression tag
Ser -30	-	expression tag
His -29	-	expression tag
His -28	-	expression tag
His -27	-	expression tag
His -26	-	expression tag
His -25	-	expression tag
His -24	-	expression tag
Ser -23	-	expression tag
Ser -22	-	expression tag
Gly -21	-	expression tag
Leu -20	-	expression tag
Val -19	-	expression tag
Pro -18	-	expression tag
Arg -17	-	expression tag
Gly -16	-	expression tag
Ser -15	-	expression tag
His -14	-	expression tag
Met -13	-	expression tag
Ala -12	-	expression tag
Ser -11	-	expression tag
Met -10	-	expression tag
Thr -9	-	expression tag
Gly -8	-	expression tag
Gly -7	-	expression tag
Gln -6	-	expression tag
Gln -5	-	expression tag
Met -4	-	expression tag
Gly -3	-	expression tag
Arg -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Thr 103	Ala 103	engineered mutation
Ser 327	Gly 327	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	49845.6
Non-Polymers*	Number of molecules	29
	Total formula weight	904.9
All*	Total formula weight	50750.6

*Water molecules are not included.