Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
| A | 0015936 | biological_process | coenzyme A metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0140643 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADH) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE CIT A 502 |
| Chain | Residue |
| A | GLU81 |
| A | NA1008 |
| A | HOH1074 |
| A | HOH1075 |
| A | HOH1077 |
| A | HOH1083 |
| A | HOH1094 |
| A | ARG257 |
| A | THR260 |
| A | LYS263 |
| A | GLY264 |
| A | ASN267 |
| A | ALA365 |
| A | LEU369 |
| A | NA1001 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 501 |
| Chain | Residue |
| A | TYR144 |
| A | ARG150 |
| A | GLY182 |
| A | MET185 |
| A | LYS325 |
| A | HOH1113 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 997 |
| Chain | Residue |
| A | VAL105 |
| A | GLN107 |
| A | SER217 |
| A | VAL219 |
| A | NA1015 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 998 |
| Chain | Residue |
| A | ILE274 |
| A | GLY277 |
| A | SER328 |
| A | NA1016 |
| A | NA1019 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 999 |
| Chain | Residue |
| A | ILE283 |
| A | GLY286 |
| A | ALA287 |
| A | PRO319 |
| A | NA1010 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 1000 |
| Chain | Residue |
| A | ALA87 |
| A | GLN361 |
| A | ALA365 |
| A | NA1001 |
| A | HOH1083 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NA A 1001 |
| Chain | Residue |
| A | CIT502 |
| A | NA1000 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 1002 |
| Chain | Residue |
| A | GLN113 |
| A | ILE209 |
| A | LEU210 |
| A | TYR256 |
| A | ARG257 |
| A | THR260 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 1003 |
| Chain | Residue |
| A | SER49 |
| A | GLU50 |
| A | GLU81 |
| A | SER83 |
| A | VAL84 |
| A | VAL85 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 1004 |
| Chain | Residue |
| A | SER27 |
| A | PRO28 |
| A | GLU29 |
| A | SER222 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 1005 |
| Chain | Residue |
| A | GLN107 |
| A | THR215 |
| A | ASP216 |
| A | SER217 |
| A | LEU218 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 1006 |
| Chain | Residue |
| A | LYS263 |
| A | PHE266 |
| A | ARG281 |
| A | GLU284 |
| A | HIS288 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 1007 |
| Chain | Residue |
| A | SER49 |
| A | PRO59 |
| A | SER61 |
| A | TYR77 |
| A | THR79 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 1008 |
| Chain | Residue |
| A | HIS261 |
| A | GLY264 |
| A | ASN362 |
| A | ALA365 |
| A | CIT502 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 1009 |
| Chain | Residue |
| A | SER248 |
| A | ALA251 |
| A | GLN252 |
| A | SER301 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 1010 |
| Chain | Residue |
| A | ASN212 |
| A | ALA282 |
| A | PRO321 |
| A | NA999 |
| A | NA1018 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 1011 |
| Chain | Residue |
| A | TYR13 |
| A | LEU34 |
| A | ASP37 |
| A | VAL53 |
| A | GLY54 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA A 1012 |
| Chain | Residue |
| A | ARG108 |
| A | THR177 |
| A | HOH1057 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA A 1013 |
| Chain | Residue |
| A | SER33 |
| A | GLU38 |
| A | ARG334 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 1014 |
| Chain | Residue |
| A | ILE111 |
| A | SER211 |
| A | ALA214 |
| A | HOH1121 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 1015 |
| Chain | Residue |
| A | ARG108 |
| A | MET320 |
| A | ALA351 |
| A | NA997 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 1016 |
| Chain | Residue |
| A | GLU80 |
| A | ASN278 |
| A | TRP280 |
| A | NA998 |
| site_id | CC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 1017 |
| Chain | Residue |
| A | ALA247 |
| A | ALA251 |
| A | ARG257 |
| A | HIS261 |
| A | LEU366 |
| site_id | CC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 1018 |
| Chain | Residue |
| A | ASN212 |
| A | ALA282 |
| A | PRO321 |
| A | NA1010 |
| A | HOH1125 |
| site_id | CC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 1019 |
| Chain | Residue |
| A | LEU58 |
| A | SER328 |
| A | ASN332 |
| A | NA998 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 1020 |
| Chain | Residue |
| A | SER9 |
| A | ARG16 |
| A | GLU50 |
| A | ASN51 |
| A | HOH1027 |
| site_id | CC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NA A 1021 |
| site_id | DC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NA A 1022 |
| site_id | DC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NA A 1023 |
| Chain | Residue |
| A | ASN344 |
| A | HOH1037 |
Functional Information from PROSITE/UniProt
| site_id | PS01192 |
| Number of Residues | 14 |
| Details | HMG_COA_REDUCTASE_3 Hydroxymethylglutaryl-coenzyme A reductases signature 3. ALvStgIqQGHMkL |
| Chain | Residue | Details |
| A | ALA368-LEU381 | |
