3Q95

Crystal structure of human estrogen receptor alpha LBD in complex with GRIP peptide and estriol

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Estrogen receptor	polymer	260	29647.9	1	UniProt (P03372) Pfam (PF00104)	Homo sapiens (human)	ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1
2	B (B)	Estrogen receptor	polymer	260	29724.0	1	UniProt (P03372) Pfam (PF00104)	Homo sapiens (human)	ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1
3	C, D (C, D)	Nuclear receptor coactivator 2	polymer	13	1579.9	2	UniProt (Q15596)	Homo sapiens	NCoA-2, Class E basic helix-loop-helix protein 75, bHLHe75, Transcriptional intermediary factor 2, hTIF2
4	E, J (A, B)	ESTRIOL	non-polymer		288.4	2	Chemie (ESL)
5	F, G, H, I (A)	CHLORIDE ION	non-polymer		35.5	4	Chemie (CL)
6	K, L, M (A, B, C)	water	water		18.0	80	Chemie (HOH)

Sequence modifications

A: 298 - 554 (UniProt: P03372)

PDB	External Database	Details
Ser 295	-	expression tag
Asn 296	-	expression tag
Ala 297	-	expression tag
Ser 537	Tyr 537	engineered mutation

B: 298 - 554 (UniProt: P03372)

PDB	External Database	Details
Ser 295	-	expression tag
Asn 296	-	expression tag
Ala 297	-	expression tag
Ser 537	Tyr 537	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	62531.7
Non-Polymers*	Number of molecules	6
	Total formula weight	718.6
All*	Total formula weight	63250.2

*Water molecules are not included.