3PXK
FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH Pyrrolo[2,3-d]thiazole
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | PTK2 protein | polymer | 282 | 32304.2 | 2 | UniProt (Q8IYN9) Pfam (PF07714) UniProt (by SIFTS) (Q05397) | Homo sapiens (human) | |
| 2 | C, E (A, B) | 6-(4,4-dimethylpent-2-ynyl)-4~{H}-pyrrolo[2,3-d][1,3]thiazole | non-polymer | 218.3 | 2 | Chemie (PXK) | |||
| 3 | D (B) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 381 | Chemie (HOH) |
Sequence modifications
A, B: 410 - 689 (UniProt: Q8IYN9)
| PDB | External Database | Details |
|---|---|---|
| Gly 408 | - | expression tag |
| Ser 409 | - | expression tag |
| Gly 410 | Pro 410 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64608.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 532.7 | |
| All* | Total formula weight | 65141.1 |
