3PKI
Human SIRT6 crystal structure in complex with ADP ribose
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | NAD-dependent deacetylase sirtuin-6 | polymer | 355 | 39106.7 | 6 | UniProt (Q8N6T7) Pfam (PF02146) | Homo sapiens (human) | SIR2-like protein 6 |
| 2 | DB, EB, G, GA, HA... (E, A, C, F, B...) | UNKNOWN ATOM OR ION | non-polymer | 26 | Chemie (UNX) | ||||
| 3 | AA, FB, H, NA, P... (C, F, A, D, B...) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 4 | BA, GB, J, OA, Q... (C, F, A, D, B...) | [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | non-polymer | 559.3 | 6 | Chemie (AR6) | |||
| 5 | AB, BB, CA, CB, DA... (E, C, F, A, D...) | SULFATE ION | non-polymer | 96.1 | 23 | Chemie (SO4) | |||
| 6 | PB, QB, RB, SB, TB... (A, B, C, D, E...) | water | water | 18.0 | 939 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 0 - 353 (UniProt: Q8N6T7)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Glu 265 | Lys 267 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 234640.2 | |
| Non-Polymers* | Number of molecules | 61 |
| Total formula weight | 5957.8 | |
| All* | Total formula weight | 240598.0 |
