3PKI
Human SIRT6 crystal structure in complex with ADP ribose
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | NAD-dependent deacetylase sirtuin-6 | polymer | 355 | 39106.7 | 6 | UniProt (Q8N6T7) Pfam (PF02146) | Homo sapiens (human) | SIR2-like protein 6 |
| 2 | DB, EB, G, GA, HA... (E, A, C, F, B...) | UNKNOWN ATOM OR ION | non-polymer | 26 | Chemie (UNX) | ||||
| 3 | AA, FB, H, NA, P... (C, F, A, D, B...) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 4 | BA, GB, J, OA, Q... (C, F, A, D, B...) | [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | non-polymer | 559.3 | 6 | Chemie (AR6) PubChem (192) PubChem (25113622) PubChem (25113623) PubChem (44415180) PubChem (51051599) PubChem (44144391) PubChem (445794) PubChem (447048) PubChem (89379870) PubChem (33576) PubChem (447165) PubChem (448826) PubChem (91746164) PubChem (9548001) PubChem (9547960) PubChem (122606931) PubChem (122609061) PubChem (10437766) PubChem (174159053) PubChem (140853820) PubChem (146879505) PubChem (162774256) PubChem (162782217) PubChem (163972867) PubChem (173750345) PubChem (173750346) PubChem (175675949) | |||
| 5 | AB, BB, CA, CB, DA... (E, C, F, A, D...) | SULFATE ION | non-polymer | 96.1 | 23 | Chemie (SO4) | |||
| 6 | PB, QB, RB, SB, TB... (A, B, C, D, E...) | water | water | 18.0 | 939 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 0 - 353 (UniProt: Q8N6T7)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Glu 265 | Lys 267 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 234640.2 | |
| Non-Polymers* | Number of molecules | 61 |
| Total formula weight | 5957.8 | |
| All* | Total formula weight | 240598.0 |
