3PKI

Human SIRT6 crystal structure in complex with ADP ribose

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0003684	molecular_function	damaged DNA binding
A	0003714	molecular_function	transcription corepressor activity
A	0003723	molecular_function	RNA binding
A	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005721	cellular_component	pericentric heterochromatin
A	0005730	cellular_component	nucleolus
A	0005783	cellular_component	endoplasmic reticulum
A	0006111	biological_process	regulation of gluconeogenesis
A	0006281	biological_process	DNA repair
A	0006282	biological_process	regulation of DNA repair
A	0006284	biological_process	base-excision repair
A	0006302	biological_process	double-strand break repair
A	0006325	biological_process	chromatin organization
A	0006338	biological_process	chromatin remodeling
A	0006476	biological_process	protein deacetylation
A	0006606	biological_process	protein import into nucleus
A	0006974	biological_process	DNA damage response
A	0008270	molecular_function	zinc ion binding
A	0008285	biological_process	negative regulation of cell population proliferation
A	0008340	biological_process	determination of adult lifespan
A	0009411	biological_process	response to UV
A	0010526	biological_process	transposable element silencing
A	0010569	biological_process	regulation of double-strand break repair via homologous recombination
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0017136	molecular_function	histone deacetylase activity, NAD-dependent
A	0019216	biological_process	regulation of lipid metabolic process
A	0031490	molecular_function	chromatin DNA binding
A	0031491	molecular_function	nucleosome binding
A	0031508	biological_process	pericentric heterochromatin formation
A	0031509	biological_process	subtelomeric heterochromatin formation
A	0031648	biological_process	protein destabilization
A	0032024	biological_process	positive regulation of insulin secretion
A	0032129	molecular_function	histone H3K9 deacetylase activity, hydrolytic mechanism
A	0032206	biological_process	positive regulation of telomere maintenance
A	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0032922	biological_process	circadian regulation of gene expression
A	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
A	0034979	molecular_function	NAD-dependent protein lysine deacetylase activity
A	0035861	cellular_component	site of double-strand break
A	0042181	biological_process	ketone biosynthetic process
A	0042308	biological_process	negative regulation of protein import into nucleus
A	0042593	biological_process	glucose homeostasis
A	0042752	biological_process	regulation of circadian rhythm
A	0042803	molecular_function	protein homodimerization activity
A	0043687	biological_process	post-translational protein modification
A	0045600	biological_process	positive regulation of fat cell differentiation
A	0045721	biological_process	negative regulation of gluconeogenesis
A	0045814	biological_process	negative regulation of gene expression, epigenetic
A	0045820	biological_process	negative regulation of glycolytic process
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046325	biological_process	negative regulation of D-glucose import
A	0046827	biological_process	positive regulation of protein export from nucleus
A	0046872	molecular_function	metal ion binding
A	0046969	molecular_function	histone H3K9 deacetylase activity, NAD-dependent
A	0048146	biological_process	positive regulation of fibroblast proliferation
A	0050708	biological_process	regulation of protein secretion
A	0050994	biological_process	regulation of lipid catabolic process
A	0051697	biological_process	protein delipidation
A	0055007	biological_process	cardiac muscle cell differentiation
A	0070403	molecular_function	NAD+ binding
A	0090734	cellular_component	site of DNA damage
A	0097372	molecular_function	histone H3K18 deacetylase activity, NAD-dependent
A	0099115	cellular_component	chromosome, subtelomeric region
A	0106222	molecular_function	lncRNA binding
A	0106274	molecular_function	NAD+-protein-arginine ADP-ribosyltransferase activity
A	0120162	biological_process	positive regulation of cold-induced thermogenesis
A	0120186	biological_process	negative regulation of protein localization to chromatin
A	0120187	biological_process	positive regulation of protein localization to chromatin
A	0140612	molecular_function	DNA damage sensor activity
A	0140765	molecular_function	histone H3K56 deacetylase activity, NAD-dependent
A	0140773	molecular_function	NAD-dependent protein demyristoylase activity
A	0140774	molecular_function	NAD-dependent protein depalmitoylase activity
A	0140804	molecular_function	NAD+-protein-lysine ADP-ribosyltransferase activity
A	0140861	biological_process	DNA repair-dependent chromatin remodeling
A	1902459	biological_process	positive regulation of stem cell population maintenance
A	1902732	biological_process	positive regulation of chondrocyte proliferation
A	1903076	biological_process	regulation of protein localization to plasma membrane
A	1904841	molecular_function	TORC2 complex binding
A	1905555	biological_process	positive regulation of blood vessel branching
A	1905564	biological_process	positive regulation of vascular endothelial cell proliferation
A	1990166	biological_process	protein localization to site of double-strand break
A	1990404	molecular_function	NAD+-protein mono-ADP-ribosyltransferase activity
A	2000648	biological_process	positive regulation of stem cell proliferation
A	2000738	biological_process	positive regulation of stem cell differentiation
A	2000773	biological_process	negative regulation of cellular senescence
A	2000781	biological_process	positive regulation of double-strand break repair
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000781	cellular_component	chromosome, telomeric region
B	0000785	cellular_component	chromatin
B	0003677	molecular_function	DNA binding
B	0003682	molecular_function	chromatin binding
B	0003684	molecular_function	damaged DNA binding
B	0003714	molecular_function	transcription corepressor activity
B	0003723	molecular_function	RNA binding
B	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0005721	cellular_component	pericentric heterochromatin
B	0005730	cellular_component	nucleolus
B	0005783	cellular_component	endoplasmic reticulum
B	0006111	biological_process	regulation of gluconeogenesis
B	0006281	biological_process	DNA repair
B	0006282	biological_process	regulation of DNA repair
B	0006284	biological_process	base-excision repair
B	0006302	biological_process	double-strand break repair
B	0006325	biological_process	chromatin organization
B	0006338	biological_process	chromatin remodeling
B	0006476	biological_process	protein deacetylation
B	0006606	biological_process	protein import into nucleus
B	0006974	biological_process	DNA damage response
B	0008270	molecular_function	zinc ion binding
B	0008285	biological_process	negative regulation of cell population proliferation
B	0008340	biological_process	determination of adult lifespan
B	0009411	biological_process	response to UV
B	0010526	biological_process	transposable element silencing
B	0010569	biological_process	regulation of double-strand break repair via homologous recombination
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0017136	molecular_function	histone deacetylase activity, NAD-dependent
B	0019216	biological_process	regulation of lipid metabolic process
B	0031490	molecular_function	chromatin DNA binding
B	0031491	molecular_function	nucleosome binding
B	0031508	biological_process	pericentric heterochromatin formation
B	0031509	biological_process	subtelomeric heterochromatin formation
B	0031648	biological_process	protein destabilization
B	0032024	biological_process	positive regulation of insulin secretion
B	0032129	molecular_function	histone H3K9 deacetylase activity, hydrolytic mechanism
B	0032206	biological_process	positive regulation of telomere maintenance
B	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
B	0032922	biological_process	circadian regulation of gene expression
B	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
B	0034979	molecular_function	NAD-dependent protein lysine deacetylase activity
B	0035861	cellular_component	site of double-strand break
B	0042181	biological_process	ketone biosynthetic process
B	0042308	biological_process	negative regulation of protein import into nucleus
B	0042593	biological_process	glucose homeostasis
B	0042752	biological_process	regulation of circadian rhythm
B	0042803	molecular_function	protein homodimerization activity
B	0043687	biological_process	post-translational protein modification
B	0045600	biological_process	positive regulation of fat cell differentiation
B	0045721	biological_process	negative regulation of gluconeogenesis
B	0045814	biological_process	negative regulation of gene expression, epigenetic
B	0045820	biological_process	negative regulation of glycolytic process
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0046325	biological_process	negative regulation of D-glucose import
B	0046827	biological_process	positive regulation of protein export from nucleus
B	0046872	molecular_function	metal ion binding
B	0046969	molecular_function	histone H3K9 deacetylase activity, NAD-dependent
B	0048146	biological_process	positive regulation of fibroblast proliferation
B	0050708	biological_process	regulation of protein secretion
B	0050994	biological_process	regulation of lipid catabolic process
B	0051697	biological_process	protein delipidation
B	0055007	biological_process	cardiac muscle cell differentiation
B	0070403	molecular_function	NAD+ binding
B	0090734	cellular_component	site of DNA damage
B	0097372	molecular_function	histone H3K18 deacetylase activity, NAD-dependent
B	0099115	cellular_component	chromosome, subtelomeric region
B	0106222	molecular_function	lncRNA binding
B	0106274	molecular_function	NAD+-protein-arginine ADP-ribosyltransferase activity
B	0120162	biological_process	positive regulation of cold-induced thermogenesis
B	0120186	biological_process	negative regulation of protein localization to chromatin
B	0120187	biological_process	positive regulation of protein localization to chromatin
B	0140612	molecular_function	DNA damage sensor activity
B	0140765	molecular_function	histone H3K56 deacetylase activity, NAD-dependent
B	0140773	molecular_function	NAD-dependent protein demyristoylase activity
B	0140774	molecular_function	NAD-dependent protein depalmitoylase activity
B	0140804	molecular_function	NAD+-protein-lysine ADP-ribosyltransferase activity
B	0140861	biological_process	DNA repair-dependent chromatin remodeling
B	1902459	biological_process	positive regulation of stem cell population maintenance
B	1902732	biological_process	positive regulation of chondrocyte proliferation
B	1903076	biological_process	regulation of protein localization to plasma membrane
B	1904841	molecular_function	TORC2 complex binding
B	1905555	biological_process	positive regulation of blood vessel branching
B	1905564	biological_process	positive regulation of vascular endothelial cell proliferation
B	1990166	biological_process	protein localization to site of double-strand break
B	1990404	molecular_function	NAD+-protein mono-ADP-ribosyltransferase activity
B	2000648	biological_process	positive regulation of stem cell proliferation
B	2000738	biological_process	positive regulation of stem cell differentiation
B	2000773	biological_process	negative regulation of cellular senescence
B	2000781	biological_process	positive regulation of double-strand break repair
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000781	cellular_component	chromosome, telomeric region
C	0000785	cellular_component	chromatin
C	0003677	molecular_function	DNA binding
C	0003682	molecular_function	chromatin binding
C	0003684	molecular_function	damaged DNA binding
C	0003714	molecular_function	transcription corepressor activity
C	0003723	molecular_function	RNA binding
C	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0005721	cellular_component	pericentric heterochromatin
C	0005730	cellular_component	nucleolus
C	0005783	cellular_component	endoplasmic reticulum
C	0006111	biological_process	regulation of gluconeogenesis
C	0006281	biological_process	DNA repair
C	0006282	biological_process	regulation of DNA repair
C	0006284	biological_process	base-excision repair
C	0006302	biological_process	double-strand break repair
C	0006325	biological_process	chromatin organization
C	0006338	biological_process	chromatin remodeling
C	0006476	biological_process	protein deacetylation
C	0006606	biological_process	protein import into nucleus
C	0006974	biological_process	DNA damage response
C	0008270	molecular_function	zinc ion binding
C	0008285	biological_process	negative regulation of cell population proliferation
C	0008340	biological_process	determination of adult lifespan
C	0009411	biological_process	response to UV
C	0010526	biological_process	transposable element silencing
C	0010569	biological_process	regulation of double-strand break repair via homologous recombination
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0016779	molecular_function	nucleotidyltransferase activity
C	0017136	molecular_function	histone deacetylase activity, NAD-dependent
C	0019216	biological_process	regulation of lipid metabolic process
C	0031490	molecular_function	chromatin DNA binding
C	0031491	molecular_function	nucleosome binding
C	0031508	biological_process	pericentric heterochromatin formation
C	0031509	biological_process	subtelomeric heterochromatin formation
C	0031648	biological_process	protein destabilization
C	0032024	biological_process	positive regulation of insulin secretion
C	0032129	molecular_function	histone H3K9 deacetylase activity, hydrolytic mechanism
C	0032206	biological_process	positive regulation of telomere maintenance
C	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
C	0032922	biological_process	circadian regulation of gene expression
C	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
C	0034979	molecular_function	NAD-dependent protein lysine deacetylase activity
C	0035861	cellular_component	site of double-strand break
C	0042181	biological_process	ketone biosynthetic process
C	0042308	biological_process	negative regulation of protein import into nucleus
C	0042593	biological_process	glucose homeostasis
C	0042752	biological_process	regulation of circadian rhythm
C	0042803	molecular_function	protein homodimerization activity
C	0043687	biological_process	post-translational protein modification
C	0045600	biological_process	positive regulation of fat cell differentiation
C	0045721	biological_process	negative regulation of gluconeogenesis
C	0045814	biological_process	negative regulation of gene expression, epigenetic
C	0045820	biological_process	negative regulation of glycolytic process
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0046325	biological_process	negative regulation of D-glucose import
C	0046827	biological_process	positive regulation of protein export from nucleus
C	0046872	molecular_function	metal ion binding
C	0046969	molecular_function	histone H3K9 deacetylase activity, NAD-dependent
C	0048146	biological_process	positive regulation of fibroblast proliferation
C	0050708	biological_process	regulation of protein secretion
C	0050994	biological_process	regulation of lipid catabolic process
C	0051697	biological_process	protein delipidation
C	0055007	biological_process	cardiac muscle cell differentiation
C	0070403	molecular_function	NAD+ binding
C	0090734	cellular_component	site of DNA damage
C	0097372	molecular_function	histone H3K18 deacetylase activity, NAD-dependent
C	0099115	cellular_component	chromosome, subtelomeric region
C	0106222	molecular_function	lncRNA binding
C	0106274	molecular_function	NAD+-protein-arginine ADP-ribosyltransferase activity
C	0120162	biological_process	positive regulation of cold-induced thermogenesis
C	0120186	biological_process	negative regulation of protein localization to chromatin
C	0120187	biological_process	positive regulation of protein localization to chromatin
C	0140612	molecular_function	DNA damage sensor activity
C	0140765	molecular_function	histone H3K56 deacetylase activity, NAD-dependent
C	0140773	molecular_function	NAD-dependent protein demyristoylase activity
C	0140774	molecular_function	NAD-dependent protein depalmitoylase activity
C	0140804	molecular_function	NAD+-protein-lysine ADP-ribosyltransferase activity
C	0140861	biological_process	DNA repair-dependent chromatin remodeling
C	1902459	biological_process	positive regulation of stem cell population maintenance
C	1902732	biological_process	positive regulation of chondrocyte proliferation
C	1903076	biological_process	regulation of protein localization to plasma membrane
C	1904841	molecular_function	TORC2 complex binding
C	1905555	biological_process	positive regulation of blood vessel branching
C	1905564	biological_process	positive regulation of vascular endothelial cell proliferation
C	1990166	biological_process	protein localization to site of double-strand break
C	1990404	molecular_function	NAD+-protein mono-ADP-ribosyltransferase activity
C	2000648	biological_process	positive regulation of stem cell proliferation
C	2000738	biological_process	positive regulation of stem cell differentiation
C	2000773	biological_process	negative regulation of cellular senescence
C	2000781	biological_process	positive regulation of double-strand break repair
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0000781	cellular_component	chromosome, telomeric region
D	0000785	cellular_component	chromatin
D	0003677	molecular_function	DNA binding
D	0003682	molecular_function	chromatin binding
D	0003684	molecular_function	damaged DNA binding
D	0003714	molecular_function	transcription corepressor activity
D	0003723	molecular_function	RNA binding
D	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0005721	cellular_component	pericentric heterochromatin
D	0005730	cellular_component	nucleolus
D	0005783	cellular_component	endoplasmic reticulum
D	0006111	biological_process	regulation of gluconeogenesis
D	0006281	biological_process	DNA repair
D	0006282	biological_process	regulation of DNA repair
D	0006284	biological_process	base-excision repair
D	0006302	biological_process	double-strand break repair
D	0006325	biological_process	chromatin organization
D	0006338	biological_process	chromatin remodeling
D	0006476	biological_process	protein deacetylation
D	0006606	biological_process	protein import into nucleus
D	0006974	biological_process	DNA damage response
D	0008270	molecular_function	zinc ion binding
D	0008285	biological_process	negative regulation of cell population proliferation
D	0008340	biological_process	determination of adult lifespan
D	0009411	biological_process	response to UV
D	0010526	biological_process	transposable element silencing
D	0010569	biological_process	regulation of double-strand break repair via homologous recombination
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0016757	molecular_function	glycosyltransferase activity
D	0016779	molecular_function	nucleotidyltransferase activity
D	0017136	molecular_function	histone deacetylase activity, NAD-dependent
D	0019216	biological_process	regulation of lipid metabolic process
D	0031490	molecular_function	chromatin DNA binding
D	0031491	molecular_function	nucleosome binding
D	0031508	biological_process	pericentric heterochromatin formation
D	0031509	biological_process	subtelomeric heterochromatin formation
D	0031648	biological_process	protein destabilization
D	0032024	biological_process	positive regulation of insulin secretion
D	0032129	molecular_function	histone H3K9 deacetylase activity, hydrolytic mechanism
D	0032206	biological_process	positive regulation of telomere maintenance
D	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0032922	biological_process	circadian regulation of gene expression
D	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
D	0034979	molecular_function	NAD-dependent protein lysine deacetylase activity
D	0035861	cellular_component	site of double-strand break
D	0042181	biological_process	ketone biosynthetic process
D	0042308	biological_process	negative regulation of protein import into nucleus
D	0042593	biological_process	glucose homeostasis
D	0042752	biological_process	regulation of circadian rhythm
D	0042803	molecular_function	protein homodimerization activity
D	0043687	biological_process	post-translational protein modification
D	0045600	biological_process	positive regulation of fat cell differentiation
D	0045721	biological_process	negative regulation of gluconeogenesis
D	0045814	biological_process	negative regulation of gene expression, epigenetic
D	0045820	biological_process	negative regulation of glycolytic process
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0046325	biological_process	negative regulation of D-glucose import
D	0046827	biological_process	positive regulation of protein export from nucleus
D	0046872	molecular_function	metal ion binding
D	0046969	molecular_function	histone H3K9 deacetylase activity, NAD-dependent
D	0048146	biological_process	positive regulation of fibroblast proliferation
D	0050708	biological_process	regulation of protein secretion
D	0050994	biological_process	regulation of lipid catabolic process
D	0051697	biological_process	protein delipidation
D	0055007	biological_process	cardiac muscle cell differentiation
D	0070403	molecular_function	NAD+ binding
D	0090734	cellular_component	site of DNA damage
D	0097372	molecular_function	histone H3K18 deacetylase activity, NAD-dependent
D	0099115	cellular_component	chromosome, subtelomeric region
D	0106222	molecular_function	lncRNA binding
D	0106274	molecular_function	NAD+-protein-arginine ADP-ribosyltransferase activity
D	0120162	biological_process	positive regulation of cold-induced thermogenesis
D	0120186	biological_process	negative regulation of protein localization to chromatin
D	0120187	biological_process	positive regulation of protein localization to chromatin
D	0140612	molecular_function	DNA damage sensor activity
D	0140765	molecular_function	histone H3K56 deacetylase activity, NAD-dependent
D	0140773	molecular_function	NAD-dependent protein demyristoylase activity
D	0140774	molecular_function	NAD-dependent protein depalmitoylase activity
D	0140804	molecular_function	NAD+-protein-lysine ADP-ribosyltransferase activity
D	0140861	biological_process	DNA repair-dependent chromatin remodeling
D	1902459	biological_process	positive regulation of stem cell population maintenance
D	1902732	biological_process	positive regulation of chondrocyte proliferation
D	1903076	biological_process	regulation of protein localization to plasma membrane
D	1904841	molecular_function	TORC2 complex binding
D	1905555	biological_process	positive regulation of blood vessel branching
D	1905564	biological_process	positive regulation of vascular endothelial cell proliferation
D	1990166	biological_process	protein localization to site of double-strand break
D	1990404	molecular_function	NAD+-protein mono-ADP-ribosyltransferase activity
D	2000648	biological_process	positive regulation of stem cell proliferation
D	2000738	biological_process	positive regulation of stem cell differentiation
D	2000773	biological_process	negative regulation of cellular senescence
D	2000781	biological_process	positive regulation of double-strand break repair
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0000781	cellular_component	chromosome, telomeric region
E	0000785	cellular_component	chromatin
E	0003677	molecular_function	DNA binding
E	0003682	molecular_function	chromatin binding
E	0003684	molecular_function	damaged DNA binding
E	0003714	molecular_function	transcription corepressor activity
E	0003723	molecular_function	RNA binding
E	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0005721	cellular_component	pericentric heterochromatin
E	0005730	cellular_component	nucleolus
E	0005783	cellular_component	endoplasmic reticulum
E	0006111	biological_process	regulation of gluconeogenesis
E	0006281	biological_process	DNA repair
E	0006282	biological_process	regulation of DNA repair
E	0006284	biological_process	base-excision repair
E	0006302	biological_process	double-strand break repair
E	0006325	biological_process	chromatin organization
E	0006338	biological_process	chromatin remodeling
E	0006476	biological_process	protein deacetylation
E	0006606	biological_process	protein import into nucleus
E	0006974	biological_process	DNA damage response
E	0008270	molecular_function	zinc ion binding
E	0008285	biological_process	negative regulation of cell population proliferation
E	0008340	biological_process	determination of adult lifespan
E	0009411	biological_process	response to UV
E	0010526	biological_process	transposable element silencing
E	0010569	biological_process	regulation of double-strand break repair via homologous recombination
E	0016740	molecular_function	transferase activity
E	0016746	molecular_function	acyltransferase activity
E	0016757	molecular_function	glycosyltransferase activity
E	0016779	molecular_function	nucleotidyltransferase activity
E	0017136	molecular_function	histone deacetylase activity, NAD-dependent
E	0019216	biological_process	regulation of lipid metabolic process
E	0031490	molecular_function	chromatin DNA binding
E	0031491	molecular_function	nucleosome binding
E	0031508	biological_process	pericentric heterochromatin formation
E	0031509	biological_process	subtelomeric heterochromatin formation
E	0031648	biological_process	protein destabilization
E	0032024	biological_process	positive regulation of insulin secretion
E	0032129	molecular_function	histone H3K9 deacetylase activity, hydrolytic mechanism
E	0032206	biological_process	positive regulation of telomere maintenance
E	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
E	0032922	biological_process	circadian regulation of gene expression
E	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
E	0034979	molecular_function	NAD-dependent protein lysine deacetylase activity
E	0035861	cellular_component	site of double-strand break
E	0042181	biological_process	ketone biosynthetic process
E	0042308	biological_process	negative regulation of protein import into nucleus
E	0042593	biological_process	glucose homeostasis
E	0042752	biological_process	regulation of circadian rhythm
E	0042803	molecular_function	protein homodimerization activity
E	0043687	biological_process	post-translational protein modification
E	0045600	biological_process	positive regulation of fat cell differentiation
E	0045721	biological_process	negative regulation of gluconeogenesis
E	0045814	biological_process	negative regulation of gene expression, epigenetic
E	0045820	biological_process	negative regulation of glycolytic process
E	0045892	biological_process	negative regulation of DNA-templated transcription
E	0046325	biological_process	negative regulation of D-glucose import
E	0046827	biological_process	positive regulation of protein export from nucleus
E	0046872	molecular_function	metal ion binding
E	0046969	molecular_function	histone H3K9 deacetylase activity, NAD-dependent
E	0048146	biological_process	positive regulation of fibroblast proliferation
E	0050708	biological_process	regulation of protein secretion
E	0050994	biological_process	regulation of lipid catabolic process
E	0051697	biological_process	protein delipidation
E	0055007	biological_process	cardiac muscle cell differentiation
E	0070403	molecular_function	NAD+ binding
E	0090734	cellular_component	site of DNA damage
E	0097372	molecular_function	histone H3K18 deacetylase activity, NAD-dependent
E	0099115	cellular_component	chromosome, subtelomeric region
E	0106222	molecular_function	lncRNA binding
E	0106274	molecular_function	NAD+-protein-arginine ADP-ribosyltransferase activity
E	0120162	biological_process	positive regulation of cold-induced thermogenesis
E	0120186	biological_process	negative regulation of protein localization to chromatin
E	0120187	biological_process	positive regulation of protein localization to chromatin
E	0140612	molecular_function	DNA damage sensor activity
E	0140765	molecular_function	histone H3K56 deacetylase activity, NAD-dependent
E	0140773	molecular_function	NAD-dependent protein demyristoylase activity
E	0140774	molecular_function	NAD-dependent protein depalmitoylase activity
E	0140804	molecular_function	NAD+-protein-lysine ADP-ribosyltransferase activity
E	0140861	biological_process	DNA repair-dependent chromatin remodeling
E	1902459	biological_process	positive regulation of stem cell population maintenance
E	1902732	biological_process	positive regulation of chondrocyte proliferation
E	1903076	biological_process	regulation of protein localization to plasma membrane
E	1904841	molecular_function	TORC2 complex binding
E	1905555	biological_process	positive regulation of blood vessel branching
E	1905564	biological_process	positive regulation of vascular endothelial cell proliferation
E	1990166	biological_process	protein localization to site of double-strand break
E	1990404	molecular_function	NAD+-protein mono-ADP-ribosyltransferase activity
E	2000648	biological_process	positive regulation of stem cell proliferation
E	2000738	biological_process	positive regulation of stem cell differentiation
E	2000773	biological_process	negative regulation of cellular senescence
E	2000781	biological_process	positive regulation of double-strand break repair
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0000781	cellular_component	chromosome, telomeric region
F	0000785	cellular_component	chromatin
F	0003677	molecular_function	DNA binding
F	0003682	molecular_function	chromatin binding
F	0003684	molecular_function	damaged DNA binding
F	0003714	molecular_function	transcription corepressor activity
F	0003723	molecular_function	RNA binding
F	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0005721	cellular_component	pericentric heterochromatin
F	0005730	cellular_component	nucleolus
F	0005783	cellular_component	endoplasmic reticulum
F	0006111	biological_process	regulation of gluconeogenesis
F	0006281	biological_process	DNA repair
F	0006282	biological_process	regulation of DNA repair
F	0006284	biological_process	base-excision repair
F	0006302	biological_process	double-strand break repair
F	0006325	biological_process	chromatin organization
F	0006338	biological_process	chromatin remodeling
F	0006476	biological_process	protein deacetylation
F	0006606	biological_process	protein import into nucleus
F	0006974	biological_process	DNA damage response
F	0008270	molecular_function	zinc ion binding
F	0008285	biological_process	negative regulation of cell population proliferation
F	0008340	biological_process	determination of adult lifespan
F	0009411	biological_process	response to UV
F	0010526	biological_process	transposable element silencing
F	0010569	biological_process	regulation of double-strand break repair via homologous recombination
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity
F	0016757	molecular_function	glycosyltransferase activity
F	0016779	molecular_function	nucleotidyltransferase activity
F	0017136	molecular_function	histone deacetylase activity, NAD-dependent
F	0019216	biological_process	regulation of lipid metabolic process
F	0031490	molecular_function	chromatin DNA binding
F	0031491	molecular_function	nucleosome binding
F	0031508	biological_process	pericentric heterochromatin formation
F	0031509	biological_process	subtelomeric heterochromatin formation
F	0031648	biological_process	protein destabilization
F	0032024	biological_process	positive regulation of insulin secretion
F	0032129	molecular_function	histone H3K9 deacetylase activity, hydrolytic mechanism
F	0032206	biological_process	positive regulation of telomere maintenance
F	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
F	0032922	biological_process	circadian regulation of gene expression
F	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
F	0034979	molecular_function	NAD-dependent protein lysine deacetylase activity
F	0035861	cellular_component	site of double-strand break
F	0042181	biological_process	ketone biosynthetic process
F	0042308	biological_process	negative regulation of protein import into nucleus
F	0042593	biological_process	glucose homeostasis
F	0042752	biological_process	regulation of circadian rhythm
F	0042803	molecular_function	protein homodimerization activity
F	0043687	biological_process	post-translational protein modification
F	0045600	biological_process	positive regulation of fat cell differentiation
F	0045721	biological_process	negative regulation of gluconeogenesis
F	0045814	biological_process	negative regulation of gene expression, epigenetic
F	0045820	biological_process	negative regulation of glycolytic process
F	0045892	biological_process	negative regulation of DNA-templated transcription
F	0046325	biological_process	negative regulation of D-glucose import
F	0046827	biological_process	positive regulation of protein export from nucleus
F	0046872	molecular_function	metal ion binding
F	0046969	molecular_function	histone H3K9 deacetylase activity, NAD-dependent
F	0048146	biological_process	positive regulation of fibroblast proliferation
F	0050708	biological_process	regulation of protein secretion
F	0050994	biological_process	regulation of lipid catabolic process
F	0051697	biological_process	protein delipidation
F	0055007	biological_process	cardiac muscle cell differentiation
F	0070403	molecular_function	NAD+ binding
F	0090734	cellular_component	site of DNA damage
F	0097372	molecular_function	histone H3K18 deacetylase activity, NAD-dependent
F	0099115	cellular_component	chromosome, subtelomeric region
F	0106222	molecular_function	lncRNA binding
F	0106274	molecular_function	NAD+-protein-arginine ADP-ribosyltransferase activity
F	0120162	biological_process	positive regulation of cold-induced thermogenesis
F	0120186	biological_process	negative regulation of protein localization to chromatin
F	0120187	biological_process	positive regulation of protein localization to chromatin
F	0140612	molecular_function	DNA damage sensor activity
F	0140765	molecular_function	histone H3K56 deacetylase activity, NAD-dependent
F	0140773	molecular_function	NAD-dependent protein demyristoylase activity
F	0140774	molecular_function	NAD-dependent protein depalmitoylase activity
F	0140804	molecular_function	NAD+-protein-lysine ADP-ribosyltransferase activity
F	0140861	biological_process	DNA repair-dependent chromatin remodeling
F	1902459	biological_process	positive regulation of stem cell population maintenance
F	1902732	biological_process	positive regulation of chondrocyte proliferation
F	1903076	biological_process	regulation of protein localization to plasma membrane
F	1904841	molecular_function	TORC2 complex binding
F	1905555	biological_process	positive regulation of blood vessel branching
F	1905564	biological_process	positive regulation of vascular endothelial cell proliferation
F	1990166	biological_process	protein localization to site of double-strand break
F	1990404	molecular_function	NAD+-protein mono-ADP-ribosyltransferase activity
F	2000648	biological_process	positive regulation of stem cell proliferation
F	2000738	biological_process	positive regulation of stem cell differentiation
F	2000773	biological_process	negative regulation of cellular senescence
F	2000781	biological_process	positive regulation of double-strand break repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1000

Chain	Residue
A	CYS139
A	CYS142
A	CYS164
A	CYS175

---

site_id	AC2
Number of Residues	28
Details	BINDING SITE FOR RESIDUE AR6 A 2000

Chain	Residue
A	PHE62
A	ARG63
A	TRP69
A	GLN111
A	HIS131
A	TRP186
A	GLY212
A	THR213
A	SER214
A	ILE217
A	ASN238
A	LEU239
A	GLN240
A	GLY254
A	TYR255
A	VAL256
A	HOH369
A	HOH375
A	HOH413
A	HOH457
A	HOH489
E	ASP81
E	HOH389
A	GLY50
A	ALA51
A	GLY52
A	THR55
A	ASP61

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 356

Chain	Residue
A	VAL152
A	GLY153
A	THR160
A	ARG162
B	LYS294

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 357

Chain	Residue
A	ASP23
A	LYS31
A	ARG251
A	HIS253
A	HOH423
B	LYS13
B	GLU72

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 358

Chain	Residue
A	PRO65
A	HIS66
A	ARG74
E	LEU76
E	ALA77

---

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 359

Chain	Residue
A	HIS66
A	LYS79
A	HOH528
A	HOH915
A	HOH920
E	HIS66
E	LYS79
E	HOH404
E	HOH545

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 360

Chain	Residue
A	ARG218
A	PRO219
A	ASN222
F	ALA226
F	ARG229

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1000

Chain	Residue
B	CYS139
B	CYS142
B	CYS164
B	CYS175

---

site_id	AC9
Number of Residues	26
Details	BINDING SITE FOR RESIDUE AR6 B 2000

Chain	Residue
B	GLY50
B	ALA51
B	GLY52
B	THR55
B	ASP61
B	PHE62
B	ARG63
B	TRP69
B	GLN111
B	HIS131
B	GLY212
B	THR213
B	SER214
B	ILE217
B	ASN238
B	LEU239
B	GLN240
B	GLY254
B	TYR255
B	VAL256
B	HOH375
B	HOH377
B	HOH432
B	HOH444
F	ASP81
F	HOH432

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 360

Chain	Residue
B	VAL152
B	GLY153
B	ARG162
C	LYS294

---

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 361

Chain	Residue
B	HOH392
B	HOH421
B	HOH916
F	HIS66
F	LYS79
F	HOH641
B	HIS66
B	LYS79

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 362

Chain	Residue
B	GLU27
B	LYS31
B	ARG251
B	HIS253
B	HOH466
C	LYS13

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1000

Chain	Residue
C	CYS139
C	CYS142
C	CYS164
C	CYS175

---

site_id	BC5
Number of Residues	26
Details	BINDING SITE FOR RESIDUE AR6 C 2000

Chain	Residue
C	GLY50
C	ALA51
C	GLY52
C	THR55
C	ASP61
C	PHE62
C	ARG63
C	TRP69
C	GLN111
C	HIS131
C	GLY212
C	THR213
C	SER214
C	ILE217
C	ASN238
C	LEU239
C	GLN240
C	GLY254
C	TYR255
C	VAL256
C	HOH368
C	HOH370
C	HOH385
C	HOH398
D	ASP81
D	HOH393

---

site_id	BC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 C 361

Chain	Residue
C	ARG88
C	ALA273
C	TRP274
C	HOH399
C	HOH424
C	HOH726
D	ARG88
D	ALA273
D	TRP274

---

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 362

Chain	Residue
A	LYS294
C	VAL152
C	GLY153
C	THR160
C	ARG162

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 363

Chain	Residue
C	LYS243
C	HIS244
C	ARG246
C	HIS247

---

site_id	BC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 C 364

Chain	Residue
C	HIS66
C	LYS79
C	HOH404
C	HOH409
C	HOH464
D	HIS66
D	LYS79
D	HOH421
D	HOH431

---

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 1000

Chain	Residue
D	CYS139
D	CYS142
D	CYS164
D	CYS175

---

site_id	CC2
Number of Residues	28
Details	BINDING SITE FOR RESIDUE AR6 D 2000

Chain	Residue
C	ASP81
C	HOH405
D	GLY50
D	ALA51
D	GLY52
D	THR55
D	ASP61
D	PHE62
D	ARG63
D	TRP69
D	GLN111
D	HIS131
D	TRP186
D	GLY212
D	THR213
D	SER214
D	ILE217
D	ASN238
D	LEU239
D	GLN240
D	GLY254
D	TYR255
D	VAL256
D	HOH364
D	HOH390
D	HOH410
D	HOH428
D	HOH931

---

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 357

Chain	Residue
D	GLY153
D	ARG162
F	LYS294

---

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 358

Chain	Residue
D	LYS31
D	ARG251
D	HIS253

---

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 359

Chain	Residue
A	HIS247
D	GLY171
D	LEU172
D	ARG173

---

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 1000

Chain	Residue
E	CYS139
E	CYS142
E	CYS164
E	CYS175

---

site_id	CC7
Number of Residues	27
Details	BINDING SITE FOR RESIDUE AR6 E 2000

Chain	Residue
A	ASP81
A	HOH395
E	GLY50
E	ALA51
E	GLY52
E	THR55
E	ASP61
E	PHE62
E	ARG63
E	TRP69
E	GLN111
E	HIS131
E	GLY212
E	THR213
E	SER214
E	ILE217
E	ASN238
E	LEU239
E	GLN240
E	GLY254
E	TYR255
E	VAL256
E	HOH366
E	HOH392
E	HOH397
E	HOH417
E	HOH590

---

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 356

Chain	Residue
D	LYS294
E	VAL152
E	GLY153
E	ARG162

---

site_id	CC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 357

Chain	Residue
C	ARG180
E	ARG203
E	ARG230

---

site_id	DC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 E 358

Chain	Residue
A	ARG88
A	ALA273
A	TRP274
E	ARG88
E	ALA273
E	TRP274
E	HOH391
E	HOH721
E	HOH763

---

site_id	DC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 E 359

Chain	Residue
E	LYS31
E	ARG251

---

site_id	DC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 360

Chain	Residue
E	LYS294
F	VAL152
F	GLY153
F	THR160
F	ARG162

---

site_id	DC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 361

Chain	Residue
E	LYS243
E	HIS244
E	HIS247

---

site_id	DC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 1000

Chain	Residue
F	CYS139
F	CYS142
F	CYS164
F	CYS175

---

site_id	DC6
Number of Residues	26
Details	BINDING SITE FOR RESIDUE AR6 F 2000

Chain	Residue
B	ASP81
B	HOH401
F	GLY50
F	ALA51
F	GLY52
F	THR55
F	ASP61
F	PHE62
F	ARG63
F	TRP69
F	GLN111
F	HIS131
F	GLY212
F	THR213
F	SER214
F	ILE217
F	ASN238
F	LEU239
F	GLN240
F	GLY254
F	TYR255
F	VAL256
F	HOH372
F	HOH381
F	HOH401
F	HOH701

---

site_id	DC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 F 360

Chain	Residue
B	ARG88
B	ALA273
B	TRP274
F	ARG88
F	ALA273
F	TRP274
F	HOH637
F	HOH674

---

site_id	DC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 F 361

Chain	Residue
A	LYS243
A	HIS244
A	ARG246
A	HIS247
D	ARG170
F	ARG230
F	HOH409

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	490
Details	Domain: {"description":"Deacetylase sirtuin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	54
Details	Compositional bias: {"description":"Pro residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18337721","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23552949","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23892288","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27322069","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28406396","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21362626","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3K35","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZG6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	66
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23552949","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21362626","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3K35","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZG6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21362626","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23552949","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27990725","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3K35","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PKI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PKJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZG6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MF6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MFZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MGN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	Site: {"description":"Formation of an covalent adduct with nitro-fatty acid activators","evidences":[{"source":"PubMed","id":"33122195","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"32538779","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"24043303","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---