3PHE

HCV NS5B with a bound quinolone inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	HCV encoded nonstructural 5B protein	polymer	576	64103.5	4	UniProt (D0PY27) Pfam (PF00998)	Hepatitis C virus
2	E, F, G, H (A, B, C, D)	4-chlorobenzyl 6-fluoro-7-(4-methylpiperazin-1-yl)-1-[4-(methylsulfonyl)benzyl]-4-oxo-1,4-dihydroquinoline-3-carboxylate	non-polymer		598.1	4	Chemie (C9A)
3	I, J, K, L (A, B, C, D)	water	water		18.0	491	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 570 (UniProt: D0PY27)

PDB	External Database	Details
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	256413.9
Non-Polymers*	Number of molecules	4
	Total formula weight	2392.3
All*	Total formula weight	258806.2

*Water molecules are not included.