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3PHE

HCV NS5B with a bound quinolone inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001172biological_processRNA-templated transcription
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-directed RNA polymerase activity
A0004386molecular_functionhelicase activity
A0005524molecular_functionATP binding
A0006508biological_processproteolysis
A0008233molecular_functionpeptidase activity
A0008236molecular_functionserine-type peptidase activity
A0016740molecular_functiontransferase activity
A0016779molecular_functionnucleotidyltransferase activity
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0034062molecular_function5'-3' RNA polymerase activity
A0039694biological_processviral RNA genome replication
B0000166molecular_functionnucleotide binding
B0001172biological_processRNA-templated transcription
B0003723molecular_functionRNA binding
B0003968molecular_functionRNA-directed RNA polymerase activity
B0004386molecular_functionhelicase activity
B0005524molecular_functionATP binding
B0006508biological_processproteolysis
B0008233molecular_functionpeptidase activity
B0008236molecular_functionserine-type peptidase activity
B0016740molecular_functiontransferase activity
B0016779molecular_functionnucleotidyltransferase activity
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0034062molecular_function5'-3' RNA polymerase activity
B0039694biological_processviral RNA genome replication
C0000166molecular_functionnucleotide binding
C0001172biological_processRNA-templated transcription
C0003723molecular_functionRNA binding
C0003968molecular_functionRNA-directed RNA polymerase activity
C0004386molecular_functionhelicase activity
C0005524molecular_functionATP binding
C0006508biological_processproteolysis
C0008233molecular_functionpeptidase activity
C0008236molecular_functionserine-type peptidase activity
C0016740molecular_functiontransferase activity
C0016779molecular_functionnucleotidyltransferase activity
C0016787molecular_functionhydrolase activity
C0016887molecular_functionATP hydrolysis activity
C0034062molecular_function5'-3' RNA polymerase activity
C0039694biological_processviral RNA genome replication
D0000166molecular_functionnucleotide binding
D0001172biological_processRNA-templated transcription
D0003723molecular_functionRNA binding
D0003968molecular_functionRNA-directed RNA polymerase activity
D0004386molecular_functionhelicase activity
D0005524molecular_functionATP binding
D0006508biological_processproteolysis
D0008233molecular_functionpeptidase activity
D0008236molecular_functionserine-type peptidase activity
D0016740molecular_functiontransferase activity
D0016779molecular_functionnucleotidyltransferase activity
D0016787molecular_functionhydrolase activity
D0016887molecular_functionATP hydrolysis activity
D0034062molecular_function5'-3' RNA polymerase activity
D0039694biological_processviral RNA genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues15
DetailsBINDING SITE FOR RESIDUE C9A A 999
ChainResidue
ALEU419
AASN483
AALA486
ALEU489
APRO496
ALEU497
ATRP528
AARG422
AMET423
ALEU474
AHIS475
ASER476
ATYR477
APRO479
AILE482

site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE C9A B 998
ChainResidue
BLEU419
BARG422
BMET423
BLEU474
BHIS475
BSER476
BTYR477
BPRO479
BILE482
BALA486
BPRO496
BLEU497
BTRP528

site_idAC3
Number of Residues15
DetailsBINDING SITE FOR RESIDUE C9A C 997
ChainResidue
CLEU419
CARG422
CMET423
CLEU474
CHIS475
CSER476
CTYR477
CPRO479
CILE482
CASN483
CALA486
CLEU489
CPRO496
CLEU497
CTRP528

site_idAC4
Number of Residues16
DetailsBINDING SITE FOR RESIDUE C9A D 996
ChainResidue
DLEU419
DARG422
DMET423
DLEU474
DHIS475
DSER476
DTYR477
DPRO479
DILE482
DASN483
DVAL485
DALA486
DLEU489
DPRO496
DLEU497
DTRP528

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PDB entries from 2025-12-10

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