3P8X
Synthesis, Structure, and Biological Activity of des-Side Chain Analogues of 1alpha,25-Dihydroxyvitamin D3 with Substituents at C-18
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Vitamin D3 receptor | polymer | 280 | 31694.4 | 1 | UniProt (P11473) Pfam (PF00104) In PDB | Homo sapiens (human) | VDR, 1,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1 |
2 | A | (1R,3S,5Z)-5-{(2E)-2-[(3aR,7aS)-7a-(7-hydroxy-7-methyloctyl)octahydro-4H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol | non-polymer | 416.6 | 1 | Chemie (ZYD) | |||
3 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
4 | water | water | 18.0 | 228 | Chemie (HOH) |
Sequence modifications
A: 118 - 164 (UniProt: P11473)
A: 217 - 427 (UniProt: P11473)
PDB | External Database | Details |
---|---|---|
Met 97 | - | expression tag |
Gly 98 | - | expression tag |
Ser 99 | - | expression tag |
Ser 100 | - | expression tag |
His 101 | - | expression tag |
His 102 | - | expression tag |
His 103 | - | expression tag |
His 104 | - | expression tag |
His 105 | - | expression tag |
His 106 | - | expression tag |
Ser 107 | - | expression tag |
Ser 108 | - | expression tag |
Gly 109 | - | expression tag |
Leu 110 | - | expression tag |
Val 111 | - | expression tag |
Pro 112 | - | expression tag |
Arg 113 | - | expression tag |
Gly 114 | - | expression tag |
Ser 115 | - | expression tag |
His 116 | - | expression tag |
Met 117 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ser 216 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 31694.4 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 608.8 | |
All* | Total formula weight | 32303.2 |