3P89
FXR bound to a quinolinecarboxylic acid
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Farnesoid X receptor | polymer | 229 | 26854.7 | 1 | UniProt (B6ZGS9) Pfam (PF00104) UniProt (by SIFTS) (Q96RI1) In PDB | Homo sapiens (human) | Nuclear receptor subfamily 1, group H, member 4, isoform CRA_a |
2 | B | Nuclear receptor coactivator 1 | polymer | 11 | 1416.6 | 1 | UniProt (A8K1V4) UniProt (by SIFTS) (Q15788) In PDB | Homo sapiens (human) | Steroid receptor coactivator 1, SRC-1 |
3 | A | 6-(4-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}phenyl)quinoline-2-carboxylic acid | non-polymer | 533.4 | 1 | Chemie (89P) | |||
4 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
5 | water | water | 18.0 | 76 | Chemie (HOH) |
Sequence modifications
A: 244 - 472 (UniProt: B6ZGS9)
PDB | External Database | Details |
---|---|---|
Glu 432 | Cys 432 | engineered mutation |
Glu 466 | Cys 466 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 28271.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 629.5 | |
All* | Total formula weight | 28900.8 |