3P89

FXR bound to a quinolinecarboxylic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0032052	molecular_function	bile acid binding
A	0038183	biological_process	bile acid signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 89P A 1

Chain	Residue
A	HOH14
A	PHE329
A	ARG331
A	ILE335
A	LEU340
A	SER342
A	TYR369
A	HIS447
A	TRP454
A	TRP469
A	HOH70
A	MET265
A	THR270
A	PHE284
A	LEU287
A	THR288
A	ALA291
A	MET328

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 473

Chain	Residue
A	HOH27
A	HOH50
A	ASN271
A	LYS275
A	SER279
A	ALA280
A	ASN354

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0007744|PDB:6HL1

Chain	Residue	Details
A	ARG331
A	TYR361
A	TYR369
A	HIS447

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by PKC/PRKCZ => ECO:0000305|PubMed:18668687

Chain	Residue	Details
A	THR442

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000305|PubMed:23546875

Chain	Residue	Details
A	LYS275

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