3P5J

The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Ribonuclease H2 subunit A	polymer	301	33547.7	1	UniProt (Q9CWY8) Pfam (PF01351)	Mus musculus (mouse)	RNase H2 subunit A, Ribonuclease HI large subunit, RNase HI large subunit, Ribonuclease HI subunit A
2	B (B)	Ribonuclease H2 subunit B	polymer	332	37494.1	1	UniProt (Q80ZV0) Pfam (PF17745) Pfam (PF09468)	Mus musculus (mouse)	RNase H2 subunit B, Deleted in lymphocytic leukemia 8 homolog, Ribonuclease HI subunit B
3	C (C)	Ribonuclease H2 subunit C	polymer	166	17848.1	1	UniProt (Q9CQ18) Pfam (PF08615)	Mus musculus (mouse)	RNase H2 subunit C, Ribonuclease HI subunit C

Sequence modifications

B: 1 - 308 (UniProt: Q80ZV0)

PDB	External Database	Details
Met -23	-	expression tag
Gly -22	-	expression tag
Ser -21	-	expression tag
Ser -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
Ser -13	-	expression tag
Gln -12	-	expression tag
Asp -11	-	expression tag
Pro -10	-	expression tag
Asn -9	-	expression tag
Ser -8	-	expression tag
Leu -7	-	expression tag
Glu -6	-	expression tag
Val -5	-	expression tag
Leu -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Gly -1	-	expression tag
Pro 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	88889.9
All*	Total formula weight	88889.9

*Water molecules are not included.