3P5J
The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006298 | biological_process | mismatch repair |
| A | 0006401 | biological_process | RNA catabolic process |
| A | 0016070 | biological_process | RNA metabolic process |
| A | 0032299 | cellular_component | ribonuclease H2 complex |
| A | 1990516 | biological_process | ribonucleotide excision repair |
| B | 0001701 | biological_process | in utero embryonic development |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0006298 | biological_process | mismatch repair |
| B | 0006401 | biological_process | RNA catabolic process |
| B | 0009259 | biological_process | ribonucleotide metabolic process |
| B | 0010389 | biological_process | regulation of G2/M transition of mitotic cell cycle |
| B | 0010629 | biological_process | negative regulation of gene expression |
| B | 0032299 | cellular_component | ribonuclease H2 complex |
| B | 0048146 | biological_process | positive regulation of fibroblast proliferation |
| B | 2000001 | biological_process | regulation of DNA damage checkpoint |
| C | 0005634 | cellular_component | nucleus |
| C | 0006298 | biological_process | mismatch repair |
| C | 0006401 | biological_process | RNA catabolic process |
| C | 0032299 | cellular_component | ribonuclease H2 complex |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"O75792","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17242355","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
