3P5J
The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003676 | molecular_function | nucleic acid binding |
A | 0003723 | molecular_function | RNA binding |
A | 0004519 | molecular_function | endonuclease activity |
A | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006298 | biological_process | mismatch repair |
A | 0006401 | biological_process | RNA catabolic process |
A | 0016070 | biological_process | RNA metabolic process |
A | 0032299 | cellular_component | ribonuclease H2 complex |
A | 0046872 | molecular_function | metal ion binding |
B | 0001701 | biological_process | in utero embryonic development |
B | 0005634 | cellular_component | nucleus |
B | 0005654 | cellular_component | nucleoplasm |
B | 0006298 | biological_process | mismatch repair |
B | 0006401 | biological_process | RNA catabolic process |
B | 0009259 | biological_process | ribonucleotide metabolic process |
B | 0010389 | biological_process | regulation of G2/M transition of mitotic cell cycle |
B | 0010467 | biological_process | gene expression |
B | 0010629 | biological_process | negative regulation of gene expression |
B | 0032299 | cellular_component | ribonuclease H2 complex |
B | 0048144 | biological_process | fibroblast proliferation |
B | 0048146 | biological_process | positive regulation of fibroblast proliferation |
B | 2000001 | biological_process | regulation of DNA damage checkpoint |
C | 0005634 | cellular_component | nucleus |
C | 0006298 | biological_process | mismatch repair |
C | 0006401 | biological_process | RNA catabolic process |
C | 0032299 | cellular_component | ribonuclease H2 complex |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | MOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:Q8TDP1 |
Chain | Residue | Details |
C | MET1 | |
A | GLU35 | |
A | ASP142 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q5TBB1 |
Chain | Residue | Details |
B | LYS292 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q5TBB1 |
Chain | Residue | Details |
B | SER293 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:21183079 |
Chain | Residue | Details |
A | SER258 |