3P4F

Structural and biochemical insights into MLL1 core complex assembly and regulation.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	WD repeat-containing protein 5	polymer	317	34707.4	1	UniProt (P61964) Pfam (PF00400)	Homo sapiens (human)	BMP2-induced 3-kb gene protein
2	B (B)	Retinoblastoma-binding protein 5	polymer	11	1284.3	1	UniProt (Q15291)	Homo sapiens	RBBP-5, Retinoblastoma-binding protein RBQ-3
3	C (C)	Histone-lysine N-methyltransferase MLL	polymer	10	1063.2	1	UniProt (Q03164)	Homo sapiens	Zinc finger protein HRX, ALL-1, Trithorax-like protein, Lysine N-methyltransferase 2A
4	D, E, F (A, B, C)	water	water		18.0	244	Chemie (HOH)

Sequence modifications

A: 22 - 334 (UniProt: P61964)

PDB	External Database	Details
Gly 18	-	expression tag
Ala 19	-	expression tag
Met 20	-	expression tag
Gly 21	-	expression tag

B: 371 - 381 (UniProt: Q15291)

PDB	External Database	Details
Tyr 381	Asp 381	engineered mutation

C: 3761 - 3770 (UniProt: Q03164)

PDB	External Database	Details
Ala 3763	Ser 3763	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	37054.8
All*	Total formula weight	37054.8

*Water molecules are not included.