3P0Y

anti-EGFR/HER3 Fab DL11 in complex with domain III of EGFR extracellular region

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Epidermal growth factor receptor	polymer	214	23700.9	1	UniProt (P00533) Pfam (PF01030)	Homo sapiens (human)	Receptor tyrosine-protein kinase erbB-1, Proto-oncogene c-ErbB-1
2	B (H)	Fab DL11 heavy chain	polymer	228	24000.7	1		Homo sapiens (human)
3	C (L)	Fab DL11 light chain	polymer	214	23385.9	1		Homo sapiens (human)
4	D, F (B, D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
5	E (C)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	1	In PDB GlyTouCan (G25833JG)
6	G (H)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
7	H, I, J (A, H, L)	water	water		18.0	650	Chemie (HOH)

Sequence modifications

A: 310 - 514 (UniProt: P00533)

PDB	External Database	Details
Gly 515	-	expression tag
Asn 516	-	expression tag
Ser 517	-	expression tag
His 518	-	expression tag
His 519	-	expression tag
His 520	-	expression tag
His 521	-	expression tag
His 522	-	expression tag
His 523	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	71087.5
Branched	Number of molecules	3
	Total formula weight	1419.3
Non-Polymers*	Number of molecules	1
	Total formula weight	92.1
All*	Total formula weight	72599.0

*Water molecules are not included.