3P0Y
anti-EGFR/HER3 Fab DL11 in complex with domain III of EGFR extracellular region
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Epidermal growth factor receptor | polymer | 214 | 23700.9 | 1 | UniProt (P00533) Pfam (PF01030) In PDB | Homo sapiens (human) | Receptor tyrosine-protein kinase erbB-1, Proto-oncogene c-ErbB-1 |
2 | H | Fab DL11 heavy chain | polymer | 228 | 24000.7 | 1 | Homo sapiens (human) | ||
3 | L | Fab DL11 light chain | polymer | 214 | 23385.9 | 1 | Homo sapiens (human) | ||
4 | B, D | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
5 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G25833JG) | |||
6 | H | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
7 | water | water | 18.0 | 650 | Chemie (HOH) |
Sequence modifications
A: 310 - 514 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Gly 515 | - | expression tag |
Asn 516 | - | expression tag |
Ser 517 | - | expression tag |
His 518 | - | expression tag |
His 519 | - | expression tag |
His 520 | - | expression tag |
His 521 | - | expression tag |
His 522 | - | expression tag |
His 523 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 71087.5 | |
Branched | Number of molecules | 3 |
Total formula weight | 1419.3 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 92.1 | |
All* | Total formula weight | 72599.0 |