3OZF

Crystal Structure of Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase in complex with hypoxanthine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Hypoxanthine-guanine-xanthine phosphoribosyltransferase	polymer	250	28410.7	4	UniProt (P20035) Pfam (PF00156)	Plasmodium falciparum FCR-3/Gambia	HGXPRTase, HGXPRT, HGPRT
2	E, I, M, U (A, B, C, D)	HYPOXANTHINE	non-polymer		136.1	4	Chemie (HPA)
3	F, J, N, V (A, B, C, D)	PYROPHOSPHATE 2-	non-polymer		176.0	4	Chemie (POP)
4	G, K, O, R (A, B, C, D)	PHOSPHATE ION	non-polymer		95.0	4	Chemie (PO4)
5	H, L, P, Q, S... (A, B, C, D)	MAGNESIUM ION	non-polymer		24.3	6	Chemie (MG)
6	W, X, Y, Z (A, B, C, D)	water	water		18.0	409	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 231 (UniProt: P20035)

PDB	External Database	Details
Met -18	-	expression tag
Gly -17	-	expression tag
Gly -16	-	expression tag
Ser -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
Gly -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	113642.8
Non-Polymers*	Number of molecules	18
	Total formula weight	1774.0
All*	Total formula weight	115416.8

*Water molecules are not included.