Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3OZF

Crystal Structure of Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase in complex with hypoxanthine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0000310	molecular_function	xanthine phosphoribosyltransferase activity
A	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006166	biological_process	purine ribonucleoside salvage
A	0006178	biological_process	guanine salvage
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0032263	biological_process	GMP salvage
A	0032264	biological_process	IMP salvage
A	0032265	biological_process	XMP salvage
A	0046100	biological_process	hypoxanthine metabolic process
A	0046872	molecular_function	metal ion binding
A	0052657	molecular_function	guanine phosphoribosyltransferase activity
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0000310	molecular_function	xanthine phosphoribosyltransferase activity
B	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006166	biological_process	purine ribonucleoside salvage
B	0006178	biological_process	guanine salvage
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0032263	biological_process	GMP salvage
B	0032264	biological_process	IMP salvage
B	0032265	biological_process	XMP salvage
B	0046100	biological_process	hypoxanthine metabolic process
B	0046872	molecular_function	metal ion binding
B	0052657	molecular_function	guanine phosphoribosyltransferase activity
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0000310	molecular_function	xanthine phosphoribosyltransferase activity
C	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006166	biological_process	purine ribonucleoside salvage
C	0006178	biological_process	guanine salvage
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0032263	biological_process	GMP salvage
C	0032264	biological_process	IMP salvage
C	0032265	biological_process	XMP salvage
C	0046100	biological_process	hypoxanthine metabolic process
C	0046872	molecular_function	metal ion binding
C	0052657	molecular_function	guanine phosphoribosyltransferase activity
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0000310	molecular_function	xanthine phosphoribosyltransferase activity
D	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006166	biological_process	purine ribonucleoside salvage
D	0006178	biological_process	guanine salvage
D	0016740	molecular_function	transferase activity
D	0016757	molecular_function	glycosyltransferase activity
D	0032263	biological_process	GMP salvage
D	0032264	biological_process	IMP salvage
D	0032265	biological_process	XMP salvage
D	0046100	biological_process	hypoxanthine metabolic process
D	0046872	molecular_function	metal ion binding
D	0052657	molecular_function	guanine phosphoribosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE HPA A 232

Chain	Residue
A	TYR116
A	ILE146
A	ASP148
A	LYS176
A	PHE197
A	VAL198
A	ASP204
A	HOH298
A	HOH305

site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE POP A 233

Chain	Residue
A	LYS77
A	GLY78
A	ARG112
A	LYS114
A	SER115
A	TYR116
A	ASP204
A	ARG210
A	MG235
A	HOH237
A	HOH238
A	HOH259
A	HOH285
A	HOH298
A	HOH304
A	HOH305
A	HOH418

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 A 234

Chain	Residue
A	TYR116
A	ASP148
A	THR149
A	GLY150
A	LYS151
A	THR152
A	HOH253
A	HOH269
A	HOH304

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 235

Chain	Residue
A	ASP204
A	POP233
A	HOH237
A	HOH238
A	HOH298

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE HPA B 232

Chain	Residue
B	TYR116
B	ILE146
B	ASP148
B	LYS176
B	PHE197
B	VAL198
B	ASP204
B	PO4234
B	HOH299
B	HOH307

site_id	AC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE POP B 233

Chain	Residue
B	LYS77
B	GLY78
B	ARG112
B	LYS114
B	SER115
B	TYR116
B	ASP204
B	ARG210
B	MG235
B	HOH236
B	HOH240
B	HOH258
B	HOH307
B	HOH309

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 B 234

Chain	Residue
B	TYR116
B	ASP148
B	THR149
B	GLY150
B	LYS151
B	THR152
B	HPA232
B	HOH250
B	HOH309
B	HOH419

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 235

Chain	Residue
B	ASP204
B	POP233
B	HOH236
B	HOH240
B	HOH299

site_id	AC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE HPA C 232

Chain	Residue
C	TYR116
C	ILE146
C	ASP148
C	LYS176
C	PHE197
C	VAL198
C	ASP204
C	PO4234
C	HOH242
C	HOH300

site_id	BC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE POP C 233

Chain	Residue
C	MG236
C	HOH237
C	HOH242
C	HOH271
C	HOH285
C	HOH295
C	HOH300
C	HOH301
C	HOH305
C	LYS77
C	GLY78
C	ARG112
C	VAL113
C	LYS114
C	SER115
C	TYR116
C	ASP204
C	ARG210
C	MG235

site_id	BC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PO4 C 234

Chain	Residue
C	TYR116
C	ASP148
C	THR149
C	GLY150
C	LYS151
C	THR152
C	HPA232
C	HOH238
C	HOH246
C	HOH264
C	HOH310

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 235

Chain	Residue
C	ASP204
C	POP233
C	HOH240
C	HOH241
C	HOH242

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 236

Chain	Residue
C	POP233
C	HOH237
C	HOH238
C	HOH239
C	HOH300
C	HOH301

site_id	BC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 D 232

Chain	Residue
D	TYR116
D	ASP148
D	THR149
D	GLY150
D	LYS151
D	THR152
D	HPA235
D	HOH244
D	HOH250
D	HOH252

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D 233

Chain	Residue
D	ASP204
D	POP236
D	HOH237
D	HOH238
D	HOH239

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 234

Chain	Residue
D	POP236
D	HOH247
D	HOH252
D	HOH258
D	HOH294
D	HOH296

site_id	BC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE HPA D 235

Chain	Residue
D	TYR116
D	ILE146
D	ASP148
D	LYS176
D	PHE197
D	VAL198
D	ASP204
D	PO4232
D	HOH238
D	HOH258

site_id	BC9
Number of Residues	20
Details	BINDING SITE FOR RESIDUE POP D 236

Chain	Residue
D	LYS77
D	GLY78
D	ARG112
D	LYS114
D	SER115
D	TYR116
D	ASP204
D	ARG210
D	MG233
D	MG234
D	HOH237
D	HOH238
D	HOH239
D	HOH247
D	HOH253
D	HOH258
D	HOH288
D	HOH289
D	HOH296
D	HOH311

Functional Information from PROSITE/UniProt

site_id	PS00103
Number of Residues	13
Details	PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VLIVEDIIDTGkT

Chain	Residue	Details
A	VAL140-THR152

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	40
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10433693","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)