3OYP

HCV NS3/4A in complex with ligand 3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Serine protease NS3	polymer	187	19749.6	2	UniProt (P26662) Pfam (PF02907)	Hepatitis C virus (isolate Japanese) (HCV)	Hepacivirin, NS3P, p70
2	C, D (C, D)	Non-structural protein 4A	polymer	16	1686.1	2	UniProt (P26662)	Hepatitis C virus (isolate Japanese) (HCV)	NS4A, p8
3	E, F (E, F)	Peptidomimetic inhibitor	polymer	5	676.6	2	BIRD (PRD_000823)
4	G, H (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	I, J, K, L (A, B, C, D)	water	water		18.0	10	Chemie (HOH)

Sequence modifications

A, B: 1 - 187 (UniProt: P26662)

PDB	External Database	Details
Ile 114	Val 1140	variant
Val 132	Ile 1158	variant

C, D: 221 - 234 (UniProt: P26662)

PDB	External Database	Details
Lys 220	-	expression tag
Lys 235	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	44224.5
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	44355.3

*Water molecules are not included.