3OYP
HCV NS3/4A in complex with ligand 3
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0006508 | biological_process | proteolysis |
A | 0008236 | molecular_function | serine-type peptidase activity |
A | 0019087 | biological_process | transformation of host cell by virus |
B | 0006508 | biological_process | proteolysis |
B | 0008236 | molecular_function | serine-type peptidase activity |
B | 0019087 | biological_process | transformation of host cell by virus |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 201 |
Chain | Residue |
A | CYS97 |
A | CYS99 |
A | CYS145 |
A | HOH305 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 201 |
Chain | Residue |
B | CYS97 |
B | THR98 |
B | CYS99 |
B | CYS145 |
site_id | AC3 |
Number of Residues | 16 |
Details | BINDING SITE FOR CHAIN E OF PEPTIDOMIMETIC INHIBITOR |
Chain | Residue |
A | PHE43 |
A | HIS57 |
A | GLY58 |
A | ASP81 |
A | VAL132 |
A | LEU135 |
A | LYS136 |
A | GLY137 |
A | SER138 |
A | SER139 |
A | PHE154 |
A | ARG155 |
A | ALA156 |
A | ALA157 |
A | CYS159 |
A | GLN41 |
site_id | AC4 |
Number of Residues | 15 |
Details | BINDING SITE FOR CHAIN F OF PEPTIDOMIMETIC INHIBITOR |
Chain | Residue |
B | GLN41 |
B | SER42 |
B | PHE43 |
B | HIS57 |
B | ASP81 |
B | LEU135 |
B | LYS136 |
B | GLY137 |
B | SER138 |
B | SER139 |
B | PHE154 |
B | ARG155 |
B | ALA156 |
B | ALA157 |
B | CYS159 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166, ECO:0000305|PubMed:8389908, ECO:0000305|PubMed:8392606, ECO:0000305|PubMed:9060645 |
Chain | Residue | Details |
A | HIS57 | |
B | HIS57 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166, ECO:0000305|PubMed:8389908, ECO:0000305|PubMed:8392606 |
Chain | Residue | Details |
A | ASP81 | |
B | ASP81 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166 |
Chain | Residue | Details |
A | SER139 | |
B | SER139 |
site_id | SWS_FT_FI4 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01166, ECO:0000269|PubMed:9060645 |
Chain | Residue | Details |
A | CYS97 | |
A | CYS99 | |
A | CYS145 | |
B | CYS145 | |
B | HIS149 | |
A | HIS149 | |
B | CYS97 | |
B | CYS99 |