3OYG
Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI Compound1 (CompoundG)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | PFV integrase | polymer | 395 | 44456.7 | 2 | UniProt (P14350) Pfam (PF17921) Pfam (PF00665) Pfam (PF18103) In PDB | Human spumaretrovirus (SFVcpz(hu)) | p42In |
2 | C | DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3') | polymer | 19 | 5834.8 | 1 | |||
3 | D | DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3') | polymer | 17 | 5195.4 | 1 | |||
4 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
5 | A, B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
6 | A | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
7 | A | AMMONIUM ION | non-polymer | 18.0 | 1 | Chemie (NH4) | |||
8 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
9 | A | (6S)-2-(3-chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-6-methyl-4-(5-methyl-1,1-dioxido-1,2,5-thiadiazolidin-2-yl)-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-dione | non-polymer | 539.0 | 1 | Chemie (ZYO) | |||
10 | water | water | 18.0 | 240 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 392 (UniProt: P14350)
PDB | External Database | Details |
---|---|---|
Gly -2 | - | expression tag |
Pro -1 | - | expression tag |
Gly 0 | - | expression tag |
Ser 217 | Gly 968 | variant |
Gly 218 | Ser 969 | variant |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 99943.6 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 1255.8 | |
All* | Total formula weight | 101199.4 |