3OXU

Complement components factor H CCP19-20 and C3d in complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Complement C3	polymer	317	35444.4	3	UniProt (P01024) Pfam (PF07678) In PDB	Homo sapiens (human)	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, Complement C3 beta chain, Complement C3 alpha chain, C3a anaphylatoxin, Complement C3b alpha' chain, Complement C3c alpha' chain fragment 1, Complement C3dg fragment, Complement C3g fragment, Complement C3d fragment, Complement C3f fragment, Complement C3c alpha' chain fragment 2
2	D, E, F	HF protein	polymer	129	14773.8	3	UniProt (Q14006) Pfam (PF00084) UniProt (by SIFTS) (P08603) In PDB	Homo sapiens (human)
3	A, B, C, D, E	GLYCEROL	non-polymer		92.1	8	Chemie (GOL)
4		water	water		18.0	948	Chemie (HOH)

Sequence modifications

A, B, C: 3 - 310 (UniProt: P01024)

PDB	External Database	Details
Gly -6	-	expression tag
Pro -5	-	expression tag
Leu -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Pro -1	-	expression tag
Glu 0	-	expression tag
Phe 1	-	expression tag
Arg 2	-	expression tag
Ala 17	Cys 1010	engineered mutation

D, E, F: 1107 - 1231 (UniProt: Q14006)

PDB	External Database	Details
Glu 1103	-	expression tag
Ala 1104	-	expression tag
Glu 1105	-	expression tag
Phe 1106	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	150654.7
Non-Polymers*	Number of molecules	8
	Total formula weight	736.8
All*	Total formula weight	151391.4

*Water molecules are not included.