3OVZ
Cathepsin K in complex with a covalent inhibitor with a ketoamide warhead
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cathepsin K | polymer | 213 | 23355.3 | 1 | UniProt (P43235) Pfam (PF00112) | Homo sapiens (human) | Cathepsin O, Cathepsin O2, Cathepsin X |
| 2 | B (A) | N-[(1S)-3-amino-1-ethyl-2,3-dioxopropyl]-2-chloro-4-(pyridin-2-ylmethoxy)-3-(trifluoromethyl)benzamide | non-polymer | 443.8 | 1 | Chemie (O96) | |||
| 3 | C, D (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | E (A) | water | water | 18.0 | 79 | Chemie (HOH) |
Sequence modifications
A: 7 - 215 (UniProt: P43235)
| PDB | External Database | Details |
|---|---|---|
| Asp 3 | - | expression tag |
| Ser 4 | - | expression tag |
| Val 5 | - | expression tag |
| Asp 6 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 23355.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 635.9 | |
| All* | Total formula weight | 23991.2 |
