3OLI
Structures of human pancreatic alpha-amylase in complex with acarviostatin IV03
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Pancreatic alpha-amylase | polymer | 496 | 55980.4 | 1 | UniProt (P04746) Pfam (PF00128) Pfam (PF02806) | Homo sapiens (human) | PA, 1,4-alpha-D-glucan glucanohydrolase |
| 2 | B (B) | alpha-D-quinovopyranose-(1-4)-alpha-D-glucopyranose | branched | 326.3 | 1 | In PDB GlyTouCan (G96906VH) | |||
| 3 | C (C) | alpha-D-quinovopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 488.4 | 1 | In PDB GlyTouCan (G31885RT) | |||
| 4 | D (D) | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 504.4 | 1 | In PDB BIRD (PRD_900009) GlyTouCan (G96370VA) | alpha-maltotriose | ||
| 5 | E (E) | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 342.3 | 1 | In PDB BIRD (PRD_900001) GlyTouCan (G07411ON) | alpha-maltose | ||
| 6 | F (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 7 | G (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 8 | H (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 9 | I, J (A) | (1S,2S,3R,6R)-6-amino-4-(hydroxymethyl)cyclohex-4-ene-1,2,3-triol | non-polymer | 175.2 | 2 | Chemie (HSD) | |||
| 10 | K (A) | PYROGLUTAMIC ACID | non-polymer | 129.1 | 1 | Chemie (PCA) | |||
| 11 | L (A) | beta-D-glucopyranose | non-polymer | 180.2 | 1 | Chemie (BGC) | |||
| 12 | M, N (A) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 2 | Chemie (MPD) | |||
| 13 | O (A) | water | water | 18.0 | 501 | Chemie (HOH) |
Sequence modifications
A: 1 - 496 (UniProt: P04746)
| PDB | External Database | Details |
|---|---|---|
| Met 287 | Val 302 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 55980.4 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 1661.5 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1067.6 | |
| All* | Total formula weight | 58709.4 |
