3O63

Crystal Structure of Thiamin Phosphate Synthase from Mycobacterium tuberculosis

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Probable thiamine-phosphate pyrophosphorylase	polymer	243	25712.9	2	UniProt (P66916) Pfam (PF02581) UniProt (by SIFTS) (P9WG75)	Mycobacterium tuberculosis	TMP pyrophosphorylase, TMP-PPase, Thiamine-phosphate synthase
2	C, D (A, B)	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
3	E, F (A, B)	water	water		18.0	111	Chemie (HOH)

Sequence modifications

A, B: 1 - 222 (UniProt: P66916)

PDB	External Database	Details
Met -20	-	expression tag
Gly -19	-	expression tag
Ser -18	-	expression tag
Ser -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Glu -7	-	expression tag
Asn -6	-	expression tag
Leu -5	-	expression tag
Tyr -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Gly -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	51425.8
Non-Polymers*	Number of molecules	2
	Total formula weight	189.9
All*	Total formula weight	51615.7

*Water molecules are not included.