3O4T

Crystal Structure of HePTP with an Open WPD Loop and Partially Depleted Active Site

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Tyrosine-protein phosphatase non-receptor type 7	polymer	308	35232.8	1	UniProt (P35236) Pfam (PF00102) In PDB	Homo sapiens (human)	Protein-tyrosine phosphatase LC-PTP, Hematopoietic protein-tyrosine phosphatase, HEPTP
2	A	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
3	A	D(-)-TARTARIC ACID	non-polymer		150.1	1	Chemie (TAR)
4	A	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5		water	water		18.0	181	Chemie (HOH)

Sequence modifications

A: 44 - 339 (UniProt: P35236)

PDB	External Database	Details
Met -11	-	expression tag
Gly -10	-	expression tag
Ser -9	-	expression tag
Asp -8	-	expression tag
Lys -7	-	expression tag
Ile -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Asp 72	Ser 93	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	35232.8
Non-Polymers*	Number of molecules	4
	Total formula weight	430.3
All*	Total formula weight	35663.1

*Water molecules are not included.