3O4T

Crystal Structure of HePTP with an Open WPD Loop and Partially Depleted Active Site

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0006470	biological_process	protein dephosphorylation
A	0016311	biological_process	dephosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 1

Chain	Residue
A	CYS270
A	SER271
A	ALA272
A	ILE274
A	GLY275
A	ARG276
A	HOH427
A	HOH540
A	HOH580

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 2

Chain	Residue
A	PHE53
A	THR56
A	ALA57
A	ARG63
A	ALA330
A	GLY331
A	LEU333

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE TAR A 3

Chain	Residue
A	HIS59
A	PRO60
A	LEU61
A	THR62
A	ALA65
A	SER242
A	ALA243
A	GLY244
A	HIS324
A	LEU328

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 340

Chain	Residue
A	PRO96
A	GLY97
A	HIS98
A	ALA99
A	GLU192
A	TYR194
A	HOH465
A	HOH543

---

Functional Information from PROSITE/UniProt

site_id	PS00383
Number of Residues	11
Details	TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGigRTG

Chain	Residue	Details
A	VAL268-GLY278

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044, ECO:0000269|PubMed:9624114

Chain	Residue	Details
A	CYS270

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
A	ASP236
A	CYS270
A	GLN314

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:10206983, ECO:0007744|PubMed:18088087, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR45

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:10206983

Chain	Residue	Details
A	ASP72

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER89

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER122

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Cysteine sulfenic acid (-SOH) => ECO:0000250

Chain	Residue	Details
A	CYS270

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